Predicted genomic structure and expression patterns for GTL2. (A) Predicted genomic structure of GTL2. Black boxes and horizontal lines denote exons and introns, respectively. (*) shows the location of a single nucleotide polymorphism in exon 5 (position 86,647 of accession no. AL117190). (B) Parent-of-origin–dependent monoallelic expression of GTL2. An 85-d gestation conceptus heterozygous for the A/G polymorphism in exon 5 of GTL2 was used to determine the allelic expression ofGTL2. The maternal genotype is G/G, demonstrating paternal inheritance of the A allele in the conceptus. Analysis of RNA isolated from the indicated tissues shows exclusive expression of the maternally derived G allele (i.e., A allele is unexpressed; arrowhead).
