Sequence and Comparative Analysis of the Mouse 1-Megabase Region Orthologous to the Human 11p15 Imprinted Domain

Table 3.

Global Sequence Comparison of Human 11p15 and the Orthologous Mouse Domain

Feature Mouse Human
Total sequence 915699 bp 900050 bp
Known genes 16 16
 Exons 112 119
 Content 28710 bp 27890 bp
Novel transcripts 6 7
GC content 47.76% 54.70%
CpG islands 65 119
Conserved CpG islands 33 33
 Conserved content 17600 bp 17600 bp
Conserved nonexonic, nonisland sequences 49 49
 Conserved content 10007 bp 10007 bp
Total interspersed repeats 219 kb (23.96%) 264 kb (29.38%)
 SINEs 367 (5.24%) 215 (5.25%)
 LINEs 114 (8.08%) 192 (16.37%)
 LTR elements 170 (7.68%) 104 (6.37%)
 MERs, Mariners 20 (0.41%) 53 (1.4%)
Total simple repeats 294 (2.07%) 153 (1.92%)
 Small RNA repeats 3 (0.02%) 2 (0.02%)
 Low complexity repeats 69 (0.48%) 63 (0.54%)
  • The percent of conserved sequence (4.2%) is calculated by dividing the sum of the conserved CpG island content and non-exonic non-island content, by the aligned mouse sequence excluding the human sequence not yet completed.

This Article

  1. Genome Res. 10: 1697-1710

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