Classification of Transmembrane Protein Families in the Caenorhabditis elegans Genome and Identification of Human Orthologs

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Figure 4.
Figure 4.

Human EST sequences matching apparently worm-specific families. An ESTWISE search with a worm-specific HMM model (cluster 173) identified at least two new mammalian genes, one of which seems orthologous with aC. elegans gene. (A) Multiple alignment of the translated and assembled mammalian ESTs and their worm homologs. EST1 was assembled from mammalian EST sequences AI113283, HSM011691, and HSZZ18477. EST2 was assembled from mammalian EST sequences AI060175, MM1135871, and AA559273. (B) Phylogenetic tree of the same family, calculated with CLUSTALW.

This Article

  1. Published in Advance November 8, 2000, doi: 10.1101/gr.GR-1491R Genome Res. 10: 1679-1689

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