A Preliminary Gene Map for the Van der Woude Syndrome Critical Region Derived from 900 kb of Genomic Sequence at 1q32–q41

Table 3.

Summary of Genomic Sequence of BAC/PAC Clones from the VDWS Critical Region

Clone Accession no. Status Length Gene content
BAC 55i10 AL035408 100% 280944 VWS33, VWS34, VWS1, VWS19, LAMB3
PAC 272L16 AL023754 C 157875 VWS1, VWS19, LAMB3
PAC 28o10 AL031316 C 180130 VWS1, VWS19, LAMB3, G0S2, VWS25, HSD11, ADORA2BP
PAC 434o14 AL022398 C 135928 HSD11, ADORA2BP, VWS17, VWS14, HIRF6, VWS2
BAC 447d17 AL022728 C 161081 HSD11, ADORA2BP, VWS17, VWS14, HIRF6, VWS2
BAC 321i20 AL035046 C 169488 VWS18
PAC 782d21 AL022399 C 165590 VWS18, VWS23, VWS20
BAC 11c7 AL022397 C 109302 VWS18, VWS23, VWS20
BAC 501d19 ends only ∼175000 VWS30, VWS31
PAC 667h12 AL035414 >95% ∼143000 VWS31, VWS35, HIPP, VWS37, VWS38, RNASEH1P, VWS40
PAC 879k22 AL034351 C 137679 VWS42, VWS41
  • Clone statuses are either completely sequenced (C) by Sanger Centre and deposited in GenBank as a single continuous sequence, 100% completed by Sanger Centre except for some sequence derived by walking as detailed herein, sequence >95% completed by Sanger Centre, or sequenced at ends only.

  • The clone length is based on sequence analysis, except for clone 501d19, which is based on PFGE.

  • The gene content is based on sequence similarity searches for all clones except 501d19, which is based on STS content analysis.

This Article

  1. Genome Res. 10: 81-94

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