Uterine Dysfunction and Genetic Modifiers in Centromere Protein B-deficient Mice

Table 1.

Total Testis, Uterus, and Ovary Weight and Number of Embryos Flushed from the Oviducts of Mice on Different Genetic Backgrounds

Genetic background Av. weight ±s.d.+/+ −/− Percent reduction t-test P-value
A. Testis
R1 208.2 ± 29.4 (n = 15) 154.0 ± 37.6 (n = 16) 26 <0.001
W9.5 191.9 ± 14.3 (n = 6) 156.1 ± 17.1 (n = 7) 19 0.002
C57 186.8 ± 15.3 (n = 13) 159.9 ± 17.9 (n = 12) 14 <0.001
B. Uterus
R1 114.9 ± 23.0 (n = 6) 79.7 ± 27.8 (n = 7) 31 0.032
W9.5 122.8 ± 31.7 (n = 9) 82.5 ± 19.0 (n = 5) 33 0.024
C57 94.5 ± 14.3 (n = 10) 52.9 ± 20.1 (n = 7) 44 <0.001
C. Ovary
R1 10.4 ± 3.8 (n = 6) 11.2 ± 1.8 (n = 7) N.R. 0.635
W9.5 8.7 ± 2.1 (n = 9) 8.8 ± 2.4 (n = 5) N.R. 0.878
C57 7.3 ± 2.2 (n = 10) 8.0 ± 1.8 (n = 7) N.R. 0.513
D. No. of embryos
R1 7.8 ± 5.0 (n = 6) 4.7 ± 3.3 (n = 7) N.R. 0.198
W9.5 5.9 ± 3.5 (n = 9) 3.4 ± 3.1 (n = 5) N.R. 0.210
C57 4.9 ± 2.9 (n = 10) 4.6 ± 3.6 (n = 7) N.R. 0.838
  • Ten-week-old +/+ and −/− mice were used. Uteri, ovaries, and embryos were collected at day 0.5 of vaginal plug using previously unmated females. Weight is in mg. (N.R.) Not relevant, asP-value is insignificant.

This Article

  1. Genome Res. 10: 30-41

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