Spatially Restricted Hypopigmentation Associated with an Ednrbs -Modifying Locus on Mouse Chromosome 10

Table 5.

Test Crosses of C3H and C57BL/6J Alleles of k10 Using theMgfSl  Mutation

Hypopigmentation Mgf Sl /Mgf C3H Mgf C3H /Mgf C3H Mgf Sl /Mgf C57BL/6J Mgf C3H /Mgf C57BL/6J
Head spot F1 100% (4/4) 0% (0/4) 0% (0/14) 0% (0/14)
BC1 94% (16/17) 0% (0/13) 0% (0/13) 0% (0/11)
Dorsal spot F1 0% (0/4) 0% (0/4) 0% (0/14) 0% (0/14)
BC1 0% (0/17) 0% (0/13) 0% (0/13) 0% (0/11)

  • Ranged from several white hairs to large spot.

  • ↵From matings of C3HeBFeJ/LeMgfSl/MgfC3H; × C3HeBFeJ/Le MgfC3H (forMgfSl/MgfC3H andMgfC3H/MgfC3H mice) and C3HeBFJ/Le MgfSl/MgfC3H;× C57BL/6J MgfC57BL/6J (forMgfSl/MgfC57BL/6J andMgfC3H/MgfC57BL/6J mice). All mice are wild type at Ednrb.

  • ↵From matings of C3HeBFej/LeMgfSl/MgfC3H; × (C3HeBFeJ/Le MgfC3H × C57BL/6J MgfC57BL/6J ) F1. All mice are wild type at Ednrb.

  • ↵Fisher's exact test p < 0.001.

This Article

  1. Genome Res. 10: 17-29

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