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Method: An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns

Bowen Jin,
John A. Capra,
Penelope Benchek,
Nicholas Wheeler,
Adam C. Naj,
Kara L. Hamilton-Nelson,
John J. Farrell,
Yuk Yee Leung,
Brian Kunkle,
Badri Vadarajan,
Gerard D. Schellenberg,
Richard Mayeux,
Li-San Wang,
Lindsay A. Farrer,
Margaret A. Pericak-Vance,
Eden R. Martin,
Jonathan L. Haines,
Dana C. Crawford,
and William S. Bush

Genome Res. April 2022 32: 778-790; Published in Advance February 24, 2022, doi:10.1101/gr.276069.121

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