Empirical power and total number of false positives generated by each method over 50 simulated data sets simulated under Scenario 2 but with 201 genes (410 SNPs)
Scenario 2: Additional null genes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHISQ | GC | SLR | BLR | STR2 | AM2 | |||||||
| All SNPs included | ||||||||||||
| Power (%) | 94 | 94 | 94 | 94 | 94 | 94 | ||||||
| Total no. false +ve | 9 | 3 | 1 | 4 | 4 | 3 | ||||||
| Causal SNP excluded | ||||||||||||
| Power (%) | 72 | 68 | 68 | 72 | 74 | 76 | ||||||
| Total no. false +ve | 9 | 3 | 1 | 3 | 2 | 4 | ||||||
| Gene 1 excluded | ||||||||||||
| Total no. false +ve | 9 | 3 | 2 | 6 | 3 | 4 | ||||||