Association of ABCB1 Variants and Drug Resistance in Epileptic Patients
Variant | Phenotype | Alleles | Χ2a | Pb | Genotypes | Χ2a | Pb | r2 vs 3435C>T | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T | A | G | AT | GA | TT | GT | GG | |||||||||||||
| 2667G>T,A | Drug-resistant | 184 | 8 | 266 | 0.66 ± 0.0048c | 4 | 4 | 39 | 102 | 80 | 0.87 ± 0.0019c | 0.21 | ||||||||
| Drug-responsive | 86 | 3 | 107 | 2 | 1 | 18 | 48 | 29 | ||||||||||||
| G | T | GG | GT | TT | ||||||||||||||||
| IVS 25+3050 G>T | Drug-resistant | 286 | 284 | 2.108 | 0.147 | 69 | 148 | 68 | 2.840 | 0.242 | 0.84 | |||||||||
| Drug-responsive | 121 | 149 | 23 | 75 | 37 | |||||||||||||||
| C | T | CC | CT | TT | ||||||||||||||||
| IVS 25+5231 T>C | Drug-resistant | 259 | 291 | 0.766 | 0.381 | 57 | 145 | 73 | 1.560 | 0.458 | 0.80 | |||||||||
| Drug-responsive | 113 | 145 | 20 | 73 | 36 | |||||||||||||||
| C | T | CC | CT | TT | ||||||||||||||||
| 3435C>T | Drug-resistant | 291 | 269 | 4.509 | 0.034 | 73 | 145 | 62 | 6.855 | 0.032 | 1 | |||||||||
| Drug-responsive | 120 | 152 | 20 | 80 | 36 | |||||||||||||||
| T | C | TT | CT | CC | ||||||||||||||||
| IVS 26+80 T>C | Drug-resistant | 285 | 271 | 3.782 | 0.052 | 70 | 145 | 63 | 5.629 | 0.060 | 0.98 | |||||||||
| Drug-responsive | 118 | 150 | 20 | 78 | 36 | |||||||||||||||
a,b Χ2 and P-values for Pearson's Χ2 test of association with one (alleles) and two (genotypes) d.f.
c Fisher's exact test P and s.e.