Table 4.

Frequency of CpG Dinucleotides in the Proximity of Indel Events

10-bp window
50-bp window
Observed (CpG %)
Simulated (CpG %)
pa
Observed CpG %)
Simulated (CpG %)
pa
Slippage-like 2.54 2.90 ns 3.25 2.83 <0.001
Non-slippage-like 3.53 2.90 <0.01 3.28 2.83 <0.001
Insertion 5.30 2.87 <0.0001 3.90 2.83 <0.0001
Deletion 2.70 2.93 ns 2.71 2.83 ns
Slippage-like insertion 5.48 2.90 <0.0001 3.62 2.83 <0.0001
Slippage-like deletion 2.54 2.90 ns 2.75 2.83 ns
Non-slippage-like insertion 5.17 2.90 <0.0001 4.44 2.83 <0.0001
Non-slippage-like deletion
3.02
2.90
ns
2.91
2.83
ns

a Significance calculated as a non-paired, two-tailed t-test between the distribution of CpG dinucleotide frequencies in observed and simulated data sets. Nonsignificant values (p > 0.01) are denoted by ns