[i] The fibrate and statin signatures obtained using SPLR from the first partition of the data. Figure 1 describes the general process being followed.

Both signatures are “training signatures” in that they derived from a randomly selected 60% of the data.

Neither signatures produce training errors. The test set comprises 81 treatments of which 14 are fibrates and 15 are statins.

The fibrate signature produce two test errors and the statin signature produces four test errors. All test errors are false negatives for both signatures.

Genes are designated by their accession number, and a short description is provided.

The bias term is indicated below the weight column. Σw_ix_i is the average weighted expression summed over all signature genes. Σw_ix_i-bias, substracts the bias term.

^*Average gene expression (logratio) of each signature gene in each of the four classes.

^**Average gene expression over all members of the class multiplied by the gene specific weight. Values > 0.1 (Reward) are in green. Values < –0.1 (Penalty) are in red.

^***Annotation of each signature gene. The letter designates the affected class, and the superscript sign designates the direction of the effect (reward or penalty).