Table 3.

Summary of Sequence Similarities Between Untranslated Regions and Coding Sequences of Human and Mouse Orthologous Overlapping Genes

5′-UTR
CDS
3′-UTR
Overlap
no. of seq.
median
mean
std
no. of seq.
median
mean
std
no. of seq.
median
mean
std
Sequences that have overlaps in at least one of the species
Coding—coding 15 66.67 67.11 12.46 34 84.48 84.9 4.54 30 61.03 60.7 15.98
3UTR_Coding 102 60.96 61.75 15.09 185 85.36 84.66 4.95 165 63.23 63.35 13.52
5UTR_Coding 38 60.72 61.92 15.42 67 84.34 84 4.63 60 59.49 62.57 13.04
5UTR_5UTR 61 63.53 63.06 13.74 91 84.75 84.46 5.11 81 61.27 62.74 12.11
3UTR_3UTR 281 61.01 61.67 14.45 483 85.95 85.12 5.17 440 64.83 64.68 13.07
Sequences that have overlaps in both of the species
Coding—coding 0 0 0 N/A 0 0 0 N/A 0 0 0 N/A
3UTR_Coding 20 55.76 58.08 15.92 34 84.9 84.2 4.51 33 63.41 62.5 12.11
5UTR_Coding 1 72.7 72.7 N/A 2 88.97 88.97 2.89 2 69.48 69.48 5.79
5UTR_5UTR 3 72.52 69.53 5.33 4 86.71 85.3 6.04 4 69.48 69.94 10.97
3UTR_3UTR 74 60.7 61.26 15.41 124 85.34 85.02 4.8 120 69.06 68.27 11.47
Large scale human—mouse comparison (Makalowski and Boguski 1998)
871
67
69.7
12.9
1,138
89
86.4
12.3
938
69.4
71
12.2

[i] In bold are values that we expected to be significantly higher because of the overlap with another gene coding sequence and therefore be under higher selection against mutations.