Statistical Test for the Existence of Multiple QTLs on the Same Chromosome
Chr 1 | Chr 5 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
HDL QTL
|
LOD1
|
LOD2
|
ΔLOD2-1
|
HDL QTL
|
LOD1
|
LOD2
|
LOD3
|
ΔLOD2-1
|
ΔLOD3-2
| |||||||||
| Chow | Hdlq5 | — | — | — | Hdlq7, Hdlq1 | 10.3 | 12.5 | — | 2.2 | — | ||||||||
|
High fat
|
Hdlq5, Hdlq6
|
13.4
|
14.9
|
1.5
|
Hdlq7, Hdlq8, Hdlq1
|
7.0
|
9.4
|
11.3
|
2.4
|
1.9
| ||||||||
[i] HDL QTL refers to the significant QTLs found in single-QTL model. LOD1, LOD2, and LOD3 are LOD scores for one-QTL, two-QTL, and three-QTL models, respectively. ΔLOD2-1 = LOD2 - LOD1; ΔLOD3-2 = LOD3 - LOD2
Threshold LOD differences were computed by permutation tests: ΔLOD = 1.99 (P = 0.05), ΔLOD = 1.83 (P = 0.10), and ΔLOD = 1.58 (P = 0.20)