Table 3.

Functions in F. nucleatum sub spp vincentii That Are Not Found in F. nucleatum (FN) but Have Orthologs in Other Genomes

  1. DNA related

    1. DNA replication protein DnaC

    2. Chaperone protein DnaK (2 ORFs)

    3. RecT protein

    4. Replication initiator protein

    5. Restriction enzyme Bcql α subunit, β subunit (EC 3.1.21 -)

    6. Type I restriction-modification system methyltransferase subunit

    7. Type I restriction-modification system restriction subunit (EC 3.1.21.3)

    8. Type I restriction-modification system specificity subunit

    9. Type II restriction-modification system restriction subunit

    10. Methylcytosine-specific restriction enzyme MRR (EC 3.1.21. -)

    11. Integrase/recombinase

  2. Transporters

    1. Dipeptide transport ATP-binding protein dppD

    2. Efflux pump

    3. Ferrous iron transport protein A, Ferrous iron transport protein B

    4. Transporter, unknown

  3. Metabolic enzymes

    1. Sugar epimerase/dehydratase

    2. Ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128)

    3. UDP-galactopyranose mutase (EC 5.4.99.9)

    4. UDP-glucose 6-dehydrogenase (EC 1.1.1.22)

    5. VI polysaccharide biosynthesis protein VIPC/TVIE

    6. Ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128)

    7. Anaerobic sulfite reductase subunit A, subunit B, subunit C (EC 1.8.1 -)

    8. Cytidylate kinase (EC 2.7.4.14)

    9. Glycosyl transferase (EC 2.4.-.-) (ORFs)

    10. Glutamine synthetase (EC 6.3.1.2)

    11. Glycosyltransferase involved in cell wall biogenesis (EC 2.4.-.-)

    12. Endo-1, 4-β-xylanase (EC 3.2.1.8)

    13. L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4)

    14. Nucleotide sugar synthetase

    15. Putative hydrolase of the HD superfamily

    16. Acylneuraminate cytidylyltransferase (NeuA)

    17. N-acetylgucosamine-6-phosphate 2-epimerase (NeuC)

    18. UDP-galactoyranose mutase

    19. UDP-glucose 6-dehydrogenase

    20. UDP-glucuronate 4-epimerase

    21. Glucose-1-phosphate cytidylytransferase

    22. CDP-glucose, 4,6-dehydratase

    23. CDP-4-ketO6-deoxyglucose dehydratase

  4. Phage proteins

    1. Phage regulatory proteins (2 ORFs)

    2. Phage PBSX proteins (6 ORFs)

    3. Phage structural proteins (8 ORFs)

    4. Phage proteins (7 ORFs)

    5. Unknown phage proteins (87 ORFs)

  5. Others

    1. Membrane protein LAPB

    2. NifU-like protein

    3. ATP/GTP-binding protein

    4. Competence-damage protein CinA

    5. Gene D protein

    6. Sensor protein FixL (EC 2.7.3.-)

    7. Terminase large subunit

    8. RhuM protein

  6. Hypotheticals

    1. Hypothetical cytosolic protein (2 ORFs)

    2. Hypothetical membrane spanning protein (2 ORFs)

    3. Hypothetical protein (6 ORFs)