Table 2.

Correlation Between Protein and Regulatory Evolution: Acceleration of Protein and Regulatory Evolution in Duplicate Genes

Correlation between dN and dSM
dN/dSa
dSM/dSa
dN/dSMa
Orthologs between species rs = 0.16b,c 0.05 0.53 0.09
Duplicates within C. elegans rs = 0.24b 0.31 1.00 0.27
Duplicates within C. briggsae
rs = 0.21b
0.37
1.06
0.33

a Median values of the distribution. Pairwise comparisons between orthologs and each set of duplicates were significant (P « 10-4, Wilcoxon U-test).

b Spearman rank correlation coefficient. All correlations were significant (P < 10-4).

c Correlation is still highly significant in a multivariate analysis including dN, dS and dSM (P « 10-4).