Table 2.

The Functional Signatures of the Primary Groups


GO Term Name

# Overlapping

Genes in Term

Significance C/E

Significance E
Group 1 C/E >2 (2620)
Structural proteins 316 1576 1.21E-11 3.94E-10
Plasma membrane 247 1192 3.15E-10 1.56E-08
Transporter 268 1462 2.04E-05 1.13E-05
Metabolism 168 856 2.32E-05 4.84E-05
Signal transduction 525 1142 2.06E-04 7.00E-03
Transcription factor 154 856 1.44E-02 1.56E-02
DNA repair 13 106 1.90E-02
Wnt receptor signaling* 5 12 6.72E-03
Group 2 C/E <0.5 (1493)
Ribosome 59 139 6.11E-24 4.88E-19
RNA binding 72 374 5.53E-08 1.02E-02
Cytosol 51 226 9.44E-08 1.02E-03
Mitochondrial 65 459 1.78E-02
Cell motility* 10 108 9.56E-03
Group 3 C/E <2 to >0.5 (3842)
Signal transduction 252 1142 2.54E-82
Serine threonine kinase 29 245 4.93E-10
Proliferation 32 426 4.17E-06
Cell adhesion 31 445 4.03E-05
Cell cycle regulators 22 365 4.20E-03
Nucleic acid binding
67
1925
8.50E-04

[i] The Gene Ontology term names of the primary functional groups represented by the three major groups are shown. The number of genes that overlap with the term and the total number of genes in the term are shown for comparison. The significance value of the calculated relationship for each term from the combined data set and from the expression data alone is given next. Terms with — in the last column could not be found by expression alone. Significance was calculated from the overlap of the master list to the test list, and tested using a Bonferroni-corrected hypergeometric distribution to determine a confidence value to reject the null hypothesis. Terms with asterisks were not identified as dominant terms in the initial search, but were found to be dominate subterms in that set.