Viability of Knockouts in Yeast, PGL, and Sequence Evolution Rate
P-distancea | JTT | JTT, three-kingdom average | JTT, γ-corrected | PAM | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PGL/lethality | − | + | − | + | − | + | − | + | − | + | |||||
| 0 | 0.559 | 0.558 | 1.198 | 1.221 | 1.005 | 1.026 | 1.975 | 2.048 | 0.903 | 0.960 | |||||
| 0.02-0.2 | 0.635 | 0.625 | 1.505 | 1.457 | 1.361 | 1.324 | 2.662 | 2.535 | 1.126 | 1.099 | |||||
| 0.2-0.4 | 0.652 | 0.648 | 1.595 | 1.557 | 1.493 | 1.484 | 2.879 | 2.758 | 1.207 | 1.125 | |||||
| 0.4-0.491 | 0.669 | 0.664 | 1.643 | 1.640 | 1.538 | 1.583 | 2.935 | 2.961 | 1.412 | 1.248 | |||||
a Different methods for evolutionary distance (a surrogate for substitution rate) calculation are introduced in Methods.