Table 1.

Summary of Genes and ESTs in and Flanking the Human Xp11.2 Escape Domain, and Comparison With Mouse Orthologs

Human gene/EST
X-inactivation status
Expression
Mouse gene/EST
X-inactivation status
Expression
CpG island human/mouse
Nucleotide similarity
Amino acid identity
HADH2 Inactivated Ubiquitous Hadh2 Inactivated Ubiquitous Yes/no 76%-92% 86%
FLJ32783 Escapes Ubiquitous NM_025660 Inactivated Ubiquitous Yes/yes 74%-90% 70%
SMC1L1 Escapes Ubiquitous Smc1l1 Inactivated Ubiquitous Yes/yes 92% 99%
XM_159437-like NDa Brain/testis XM_159437 Inactivated Brain No/no 77% NDb
KIAA0522 Escapes Ubiquitous Kiaa0522 Inactivated Ubiquitous Yes/yes 85%-92% 74%
BE883792 Escapes Ubiquitous BI155935 Inactivated Ubiquitous No/no 87%-94% NDb
SMCX Escapes Ubiquitous Smcx Escapes Ubiquitous Yes/yes 90% 94%
BQ269240 Inactivated Ubiquitousc — — — No/— — —
AJ271378 Inactivated Ubiquitousc AK013346 Inactivated Ubiquitous No/no 78%-90% NDb
BF364272 Inactivatedd Ubiquitousc BE687445 Inactivated Ubiquitous No/no 84% NDb
TSPX
Inactivated
Ubiquitous
Tspx
Inactivated
Ubiquitous
Yes/yes
81%-85%
70%

ND: Not determined.

a X-inactivation status could not be determined because of tissue-restricted expression and lack of expression in fibroblasts.

b Amino acid identity was not determined for small ESTs.

c Expressed in liver and fibroblasts; other tissues not tested.

d Variable, low-level escape.