Table 1.

Rattus norvegicus BAC Libraries


Library

RPCI-32

CHORI-230
Segment
1
2
1
2
Cloning vector pBACe3.6 pBACe3.6 pTARBAC2.1 pTARBAC2.1
DNA source Male spleen Male spleen Female brain Female liver
Restriction enzyme EcoRI EcoRI EcoRI MboI
Plate range 1-288 289-624 1-240 241-528
Total 384-well dishes 288 336 240 288
Empty wells (%) 1244 (1.1%) 1559 (1.2%) 1742 (1.9%) 1677 (1.5%)
Noninsert clones (%) 4/159 (2.5%) 7/156 (4.5%) (1.1%) 26/382 (6.8%)
Recombinant clones ∼106,000 ∼122,000 ∼89,000 ∼102,000
Insert size (Average) 147 kb 153 kb 214 kb 168 kb
Standard deviation 35 kb 29 kb 27 kb 53 kb
Library redundancy
5.2-fold
6.2-fold
6.4-fold
5.5-fold

[i] The “Recombinant clones” column represents total wells after empty wells and noninsert clones were subtracted in each segment. The library redundancy was estimated using 3000 Mb as the genome size.