Table 1.

Methylation and Other Features of CpG Islands on Human Chromosome 21q

Nucleotide positione
CpG islandsa
Methylation
Repeatb
Locus
GC %c
Obs/expd
Size (bp)
Start
End
Location in the linked genef
CGI-linked genes
#1 (NT_002836.4 740746-742525) Complete methylation — 21q11.1 72.0 0.88 780 13998888 13999667 CDS Similarity to feminization 1 homolog a (C. elegans)
#2 (NT_002836.4 798428-799837) Complete methylation — 21q11.1 72.2 0.80 410 14056570 14056979 CDS Similarity to feminization 1 homolog a (C. elegans)
#3 (NT_002836.4 1099894-1101335) Complete methylation — 21q11.1 68.1 0.80 442 14358036 14358477 5′-UTR and CDS Similarity to hypothetical protein DKFZp434A171; KIAA0565; ankyrin repeat-containing proteins
#4 (NT_002836.4 2100365-2102278) Unmethylation — 21q11.2 76.2 0.98 914 15358453 15359366 5′-UTR Nuclear receptor interacting protein 1 (NRIP1)
#5 (NT_002836.4 2765740-2767861) Unmethylation — 21q11.2 74.7 0.88 1320 16023802 16025122 5′-UTR and CDS Ubiquitin specific protease 25 (USP25)
#6 (NT_002836.4 4548804-4550994) Unmethylation — 21q21.1 71.1 0.83 1229 17806771 17807999 5′-UTR and CDS Coxsackie virus and adenovirus receptor (CXADR)
#7 (NT_002836.4 4648389-4650557) Unmethylation — 21q21.1 73.4 0.96 1169 17906356 17907524 5′-UTR BTG family member 3 (BTG3)
#8 (NT_002836.4 4854926-4857042) Unmethylation — 21q21.1 68.0 0.97 1117 18112871 18113987 5′-UTR and CDS Chromosome 21 open reading frame 91 (C21 orf91), hypothetical protein LOC54149 (YG81)
#9 (NT_002836.4 12511562-12513060) Unmethylation — 21q21.2 70.3 0.88 499 25856202 25856700 —
#10 (NT_002836.4 12684911-12686522) Unmethylation — 21q21.2 71.7 0.79 612 26029550 26030161 5′-UTR ATP synthase H+ transporting mitochondrial F0 complex subunit F6
#11 (NT_002836.4 13119202-13121651) Unmethylation — 21q21.3 70.8 0.83 1450 26463778 26465227 5′-UTR and CDS Amyloid beta precursor protein (APP)
#12 (NT_002836.4 13793868-13795756) Unmethylation — 21q21.3 67.2 0.98 889 27138374 27139262 5′-UTR and CDS Matrix metalloprotease (ADAMTS1)
#13 (NT_002836.4 13915193-13916938) Unmethylation — 21q21.3 70.1 0.87 746 27259699 27260444 5′-UTR and CDS A disintegrin-like and metalloprotease with thrombospondin type 1 motif5 (ADAMTS5)
#14 (NT_002836.4 13917154-13918663) Unmethylation — 21q21.3 61.7 0.83 510 27261660 27262169 —
#15 (NT_002836.4 15834745-15836237) Unmethylation — 21q22.11 62.4 0.93 493 29179194 29179686 5′-UTR and CDS Putative N6-DNA-methyltransferase (N6AMT1)
#16 (NT_002836.4 16246692-16248676) Unmethylation — 21q22.11 76.5 0.90 985 29591133 29592117 5′-UTR BTB and CNC homology 1, basic leucine zipper transcription factor 1 (BACH1)
#17 (NT_002836.4 18506100-18509038) Incomplete methylation — 21q22.11 71.7 0.94 1939 31850340 31852278 5′-UTR Similarity to T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1)
#18 (NT_002836.4 18607855-18609856) Unmethylation — 21q22.11 69.0 0.94 1002 31952095 31953096 5′-UTR and CDS Superoxide dismutase (SOD-1)
#19 (NT_002836.4 18679791-18682057) Unmethylation — 21q22.11 74.3 0.90 1267 32024044 32025310 Similarity to CTD-binding SR-like protein rA4
#20 (NT_002836.4 18821198-18823391) Unmethylation — 21q22.11 72.7 0.87 1374 32165461 32166834 5′-UTR and CDS Hormonally up-regulated Neu-associated kinase (HUNK)
#21 (NT_002836.4 19227134-19228707) Unmethylation — 21q22.11 65.1 0.85 574 32571397 32571970 5′-UTR and CDS FAPP1-associated protein 1 (FASP1); chromosome 21 open reading frame 45 (C21orf45)
#22 (NT_002836.4 19248734-19250388) Complete methylation + 21q22.11 54.0 1.21 655 32592997 32593651 —
#23 (NT_002836.4 19359982-19362161) Unmethylation — 21q22.11 70.2 0.86 1180 32704245 32705424 —
#24 (NT_002836.4 19561116-19562518) Unmethylation — 21q22.11 62.0 0.82 403 32905379 32905781 5′-UTR Chromosome 21 open reading frame 59 (C21orf59)
#25 (NT_002836.4 19675812-19677620) Unmethylation — 21q22.11 71.4 0.83 809 33020075 33020883 5′-UTR and CDS Synaptojanin 1 (SYNJ1)
#26 (NT_002836.4 19719511-19721351) Unmethylation — 21q22.11 70.2 0.98 841 33063774 33064614 5′-UTR and CDS Chromosome 21 open reading frame 66 (C21orf66); Putative transcription factor (ORF1)
#27 (NT_002836.4 19972011-19973417) Unmethylation — 21q22.11 62.9 0.83 407 33316261 33316667 —
#28 (NT_002836.4 19975198-19977216) Unmethylation — 21q22.11 68.6 0.90 1019 33319448 33320466 5′-UTR, CDS and 3′-UTR Oligodendrocyte lineage transcription factor 2 (OLIG2)
#29 (NT_002836.4 20018303-20020533) Unmethylation — 21q22.11 73.9 0.84 1283 33362553 33363835 5′-UTR, CDS and 3′-UTR Oligodendrocyte transcription factor 1 (Olig1)
#30 (NT_002836.4 20178164-20179883) Unmethylation — 21q22.11 72.0 0.99 720 33522413 33523132 5′-UTR Interferon (alpha, beta and omega) receptor 2(IFNAR2)
#31 (NT_002836.4 20273122-20274794) Unmethylation — 21q22.11 64.7 0.93 673 33617371 33618043 5′-UTR and CDS Interferon (alpha, beta and omega) receptor 1(IFNAR1)
#32 (NT_002836.4 20351550-20353202) Unmethylation — 21q22.11 79.1 0.87 653 33695798 33696450 5′-UTR and CDS Interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2)
#33 (NT_002836.4 20427755-20429718) Unmethylation — 21q22.11 73.0 0.93 964 33772003 33772966 5′-UTR Chromosome 21 open reading frame 4 (C21orf4)
#34 (NT_002836.4 20536702-20538471) Unmethylation — 21q22.11 72.7 0.92 770 33880950 33881719 5′-UTR and CDS; 3′-UTR Downstream neighbor of SON (DONSON); Crystallin, zeta (quinone reductase)-like 1 (CRYZL1)
#35 (NT_002836.4 20590829-20592722) Unmethylation — 21q22.12 75.8 0.88 894 33935077 33935970 5′-UTR Intersectin 1 (SH3 domain protein) (ITSN1)
#36 (NT_002836.4 21021661-21023784) Unmethylation — 21q22.12 77.3 1.02 1124 34365908 34367031 5′-UTR and CDS Mitochondrial ribosomal protein S6 (MRPS6)
#37 (NT_002836.4 21323771-21325344) Unmethylation — 21q22.12 68.1 0.84 574 34668018 34668591 —
#38 (NT_002836.4 21562903-21564940) Unmethylation — 21q22.12 75.3 0.95 1038 34907150 34908187 5′-UTR and CDS Down syndrome critical region gene 1 (DSCR1)
#39 (NT_002836.4 21617860-21620045) Unmethylation + 21q22.12 75.8 0.88 1186 34962107 34963292 —
#40 (NT_002836.4 21740221-21742136) Complete methylation — 21q22.12 71.8 0.84 1064 35084468 35085531 CDS and 3′-UTR Runt-related transcription factor 1 (RUNX1); acute myeloid leukemia 1 (AML1)
#41 (NT_002836.4 21835266-21836717) Unmethylation — 21q22.12 67.2 0.79 452 35179513 35179964 5′-UTR and CDS Runt-related transcription factor 1 (RUNX1); acute myeloid leukemia 1 (AML1)
#42 (NT_002836.4 21837000-21839961) Incomplete methylation — 21q22.12 73.9 0.90 1961 35181247 35183208 5′-UTR Runt-related transcription factor 1 (RUNX1); acute myeloid leukemia 1 (AML1)
#43 (NT_002836.4 22835347-22836774) Complete methylation — 21q22.13 60.5 0.94 428 36179519 36179946 5′-UTR and CDS Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 2 (PPP1R2P2)
#44 (NT_002836.4 23008324-23010418) Unmethylation — 21q22.13 62.5 0.86 1095 36352469 36353563 5′-UTR Chromosome 21 open reading frame 18 (C21orf18)
#45 (NT_002836.4 23018419-23020042) Unmethylation — 21q22.13 70.0 0.87 624 36362564 36363187 5′-UTR and CDS Carbonyl reductase 1 (CBR1)
$46 (NT_002836.4 23083543-23085110) Unmethylation — 21q22.13 69.8 0.83 568 36427688 36428255 5′-UTR and CDS Carbonyl reductase 3 (CBR3)
#47 (NT_002836.4 23104500-23106945) Unmethylation — 21q22.13 73.0 0.78 1446 36448645 36450090 5′-UTR mRNA expressed in placenta
#48 (NT_002836.4 23268373-23270063) Unmethylation — 21q22.13 73.6 0.86 691 36612817 36613507 5′-UTR and CDS Nuclear matrix protein NXP-2 (NXP-2)
#49 (NT_002836.4 23333456-23335039) Unmethylation — 21q22.13 76.8 0.79 584 36677900 36678483 5′-UTR and CDS Similarity to chromatin assembly factor 1 subunit B (p60)
#50 (NT_002836.4 23646833-23649367) Unmethylation — 21q22.13 74.0 0.83 1535 36991300 36992834 5′-UTR and CDS Single-minded (Drosophila) homolog 2 (SIM2) transcript variant SIM2s
#51 (NT_002836.4 23648887-23650365) Unmethylation — 21q22.13 65.9 0.75 479 36993354 36993832 Intron Single-minded (Drosophila) homolog 2 (SIM2)
#52 (NT_002836.4 23657131-23658548) Unmethylation — 21q22.13 71.7 0.80 418 37001598 37002015 CDS Single-minded (Drosophila) homolog 2 (SIM2) transcript variant SIM2s
#53 (NT_002836.4 23695691-23697656) Unmethylation — 21q22.13 73.8 0.99 966 37040158 37041123 CDS and 3′-UTR Single-minded (Drosophila) homolog 2 (SIM2)
#54 (NT_002836.4 23914335-23916288) Unmethylation — 21q22.13 78.5 0.82 954 37258805 37259758 —
#55 (NT_002836.4 23928709-23930164) Composite methylation — 21q22.13 69.3 0.75 456 37273178 37273633 5′-UTR Holocarboxylase synthetase
#56 (NT_002836.4 23938177-23939758) Unmethylation — 21q22.13 74.2 0.85 582 37282645 37283226 5′-UTR Holocarboxylase synthetase
#57 (NT_002836.4 23953977-23956357) Incomplete methylation — 21q22.13 70.2 0.82 1381 37298442 37299822 5′-UTR and CDS Down syndrome critical region gene 6 (DSCR6)
#58 (NT_002836.4 24021123-24022718) Unmethylation — 21q22.13 73.6 0.90 596 37365583 37366178 5′-UTR Down syndrome critical region gene 5 (DSCR5)
#59 (NT_002836.4 24206418-24207868) Composite methylation — 21q22.13 58.3 0.90 451 37550792 37551242 Intron Down syndrome critical region gene 3 (DSCR3)
#60 (NT_002836.4 24215237-24217598) Unmethylation — 21q22.13 67.5 0.78 1362 37559611 37560972 5′-UTR and CDS Down syndrome critical region gene 3 (DSCR3)
#61 (NT_002836.4 24314183-24317285) Unmethylation — 21q22.13 75.0 0.95 2103 37658554 37660656 5′-UTR Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A)
#62 (NT_002836.4 24511883-24513479) Unmethylation — 21q22.13 67.0 0.94 597 37856254 37856850 —
#63 (NT_002836.4 25608278-25609973) Unmethylation — 21q22.2 74.5 1.04 696 38952732 38953427 5′-UTR Transcriptional regulator ERG2 gene
#64 (NT_002836.4 25753617-25755681) Unmethylation — 21q22.2 71.1 0.78 1259 39098071 39099329 5′-UTR Erythroblastosis virus oncogene homolog 2 (ets-2)
#65 (NT_002836.4 26130818-26133115) Unmethylation — 21q22.2 66.7 0.86 1298 39475251 39476548 5′-UTR and CDS Down syndrome critical region gene 2 (DSCR2)
#66 (NT_002836.4 26259167-26262261) Unmethylation — 21q22.2 71.5 0.91 2095 39604704 39606798 5′-UTR and CDS WD repeat domain 9 (WDR9)
#67 (NT_002836.4 26295243-26297124) Unmethylation — 21q22.2 76.7 0.90 882 39640780 39641661 5′-UTR and CDS High-mobility group (nonhistone chromosomal) protein 14 (HMG14)
#68 (NT_002836.4 26325240-26326648) Incomplete methylation — 21q22.2 61.8 1.02 409 39672415 39672823 5′-UTR and CDS Tryptophan rich basic protein (WRB)
#69 (NT_002836.4 26390768-26392267) Unmethylation — 21q22.2 67.8 0.91 500 39737943 39738442 5′-UTR Chromosome 21 open reading frame 13 (C21 orf13)
#70 (NT_002836.4 26556991-26558660) Unmethylation — 21q22.2 68.9 0.95 670 39904918 39905587 5′-UTR C21 orf88 protein form A (C21 orf88)
#71 (NT_002836.4 27791317-27792866) Unmethylation — 21q22.2 75.2 0.99 550 41138898 41139447 5′-UTR and CDS Down syndrome cell adhesion molecule (DSCAM)
#72 (NT_002836.4 28112154-28114765) Unmethylation — 21q22.3 73.4 0.81 1612 41459726 41461337 5′-UTR and CDS Beta-site APP-cleaving enzyme 2 (BACE2)
#73 (NT_002836.4 28452242-28454382) Unmethylation — 21q22.3 72.2 0.73 1141 41799550 41800690 —
#74 (NT_001035.5 179474-181456) Composite methylation — 21q22.3 70.9 0.87 983 42072090 42073072 5′-UTR and CDS Ankyrin repeat domain 3 (ANKRD3)
#75 (NT_003545.2 47617-49632) Complete methylation — 21q22.3 78.3 1.00 1016 42192927 42193942 CDS PR-domain zinc finger protein 15 (PRDM15)
#76 (NT_003545.2 122339-124366) Unmethylation — 21q22.3 77.2 0.87 1028 42267649 42268676 5′-UTR and CDS Similarity to human cDNA DKFZp586F0422
#77 (NT_00354.2 178197-181181) Unmethylation — 21q22.3 72.0 0.96 1985 42323507 42325491 5′-UTR Zinc finger protein 295 (ZNF295)
#78 (NT_003545.2 387867-389371) Unmethylation — 21q22.3 73.0 0.89 505 42533177 42533681 5′-UTR ABCG1 gene for ABC transporter (ATP-binding cassette, sub-family G (WHITE) member 1
#79 (NT_003545.2 403601-405007) Unmethylation — 21q22.3 72.4 1.01 407 42548911 42549317 Intron ABCG1 gene for ABC transporter (ATP-binding cassette, sub-family G (WHITE) member 1
#80 (NT_003545.2 665089-666509) Unmethylation — 21q22.3 69.8 0.78 421 42810399 42810819 5′-UTR and CDS; 5′-UTR TSGA2 mRNA for testis specific protein A2; putative glycerol 3-phosphate permease (SLC37A1)
#81 (NT_003545.2 682430-684731) Unmethylation — 21q22.3 72.8 0.83 1354 42827740 42829093 5′-UTR (exons -2, -1 and 1) Putative glycerol 3-phosphate permease (SLC37A1)
#82 (NT_003545.2 756256-760387) Complete methylation + 21q22.3 61.2 1.12 3132 42901566 42904697 —
#83 (NT_003545.2 822395-823837) Unmethylation — 21q22.3 74.7 0.81 443 42967705 42968147 5′-UTR and CDS Phosphodiesterase 9A (PDE9A)
#84 (NT_003545.2 854975-856401) Complete methylation — 21q22.3 62.3 0.86 427 43000285 43000711 CDS Phosphodiesterase 9A (PDE9A)
#85 (NT_003545.2 1017136-1019217) Complete methylation + 21q22.3 62.9 1.34 1082 43162446 43163527 3′-UTR WD repeat domain 4 (WDR4)
#86 (NT_003545.2 1047902-1049365) Unmethylation — 21q22.3 70.6 0.87 464 43193212 43193675 5′-UTR and CDS WD repeat domain 4 (WDR4)
#87 (NT_003545.2 1142956-1145447) Unmethylation — 21q22.3 76.2 0.96 1492 43288266 43289757 5′-UTR Similarity to PBX/knotted 1 homeobox 1
#88 (NT_003545.2 1243354-1246655) Incomplete methylation — 21q22.3 69.9 0.84 2302 43388664 43390965 5′-UTR Cystathionine beta-synthase (CBS)
#89 (NT_003545.2 1275925-1277810) Unmethylation — 21q22.3 72.1 0.99 886 43421235 43422120 5′-UTR and CDS U2(RNU2) small nuclear RNA auxillary factor 1
#90 (NT_002835.3 30733-32180) Complete methylation + 21q22.3 60.4 1.07 448 43574697 43575144 CDS PR-domain zinc finger protein 15 (PRDM15)
#91 (NT_002835.3 158046-161231) Unmethylation — 21q22.3 76.1 0.86 2526 43702010 43704535 5′-UTR and CDS Similarity to Mus musculus SNF1-like kinase (Snf1lk)
#92 (NT_002835.3 297286-298768) Complete methylation — 21q22.3 58.1 0.96 483 43841250 43841732 5′-UTR, CDS and 3′-UTR H2B histone family member S (LOC115376)
#93 (NT_002835.3 389981-391414) Complete methylation — 21q22.3 69.5 0.91 434 43933945 43934378 5′-UTR and CDS Heatschock transcription factor 2 binding protein (HSF2BP)
#94 (NT_002835.3 391442-393133) Unmethylation — 21q22.3 68.0 0.98 692 43935406 43936097 5′-UTR; 5′-UTR and CDS Heatshock transcription factor 2 binding protein (HSF2BP); KIAA0179 protein
#95 (NT_002835.3 450630-453100) Incomplete methylation — 21q22.3 74.4 0.92 1471 43994594 43996064 5′-UTR and CDS Pyridoxal (pyridoxine, vitamin B6) kinase (PDXK)
#96 (NT_002835.3 473197-474680) Complete methylation + 21q22.3 82.2 0.86 484 44017161 44017644 CDS Pyridoxal (pyridoxine, vitamin B6) kinase (PDXK)
#97 (NT_002835.3 508085-509942) Unmethylation — 21q22.3 72.9 0.94 858 44052049 44052906 5′-UTR and CDS Cystatin B (stefin B) (CSTB)
#98 (NT_002835.3 521399-523051) Unmethylation — 21q22.3 71.6 0.90 653 44065363 44066015 5′-UTR and CDS Novel nuclear protein 1 (NNP-1/Nop52)
#99 (NT_002835.3 596448-599173) Unmethylation — 21q22.3 80.4 0.84 1844 44140412 44142255 5′-UTR Similarity to 1-acylglycerol-3-phosphate O-acyltransferase 3
#100 (NT_002835.3 743918-746243) Unmethylation — 21q22.3 73.7 0.91 1442 44287766 44289207 5′-UTR and CDS GT334 protein (GT334); transmembrane protein 1 (TMEM1)
#101 (NT_002835.3 839100-840858) Unmethylation — 21q22.3 70.4 0.99 759 44383064 44383822 5′-UTR and CDS Periodic tryptophan protein 2 (PWP2)
#102 (NT_002835.3 865543-867041) Unmethylation — 21q22.3 69.5 0.81 499 44409507 44410005 5′-UTR and CDS Chromosome 21 open reading frame 33 (C21orf33), homolog of ES1 protein (zebrafish)
#103 (NT_002835.3 900040-901476) Composite methylation + 21q22.3 53.0 0.92 437 44444004 44444440 CDS Chromosome 21 open reading frame 32 (C21orf32)
#104 (NT_002835.3 972548-974376) Unmethylation — 21q22.3 77.6 0.84 829 44516512 44517340 5′-UTR and CDS KIAA0653 protein, Transmembrane protein B7-H2 ICOS ligand (B7-like protein)
#105 (NT_002835.3 974194-975798) Unmethylation — 21q22.3 71.4 0.79 605 44518158 44518762 —
#106 (NT_002835.3 1017861-1019307) Incomplete methylation — 21q22.3 75.1 0.83 447 44561825 44562271 5′-UTR and CDS Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (AIRE)
#107 (NT_002835.3 1031958-1033740) Unmethylation — 21q22.3 79.3 0.89 783 44575922 44576704 5′-UTR PFKL gene for liver-type 6-phosphofructokinase (EC 2.7.1.11)
#108 (NT_002835.3 1070778-1072793) Unmethylation + 21q22.3 76.2 0.85 1016 44614742 44615758 5′-UTR and CDS Chromosome 21 open reading frame 2 (C21orf2)
#109 (NT_002835.3 1082093-1084166) Unmethylation + 21q22.3 76.6 0.87 1074 44626057 44627130 —
#110 (NT_002835.3 1101487-1103181) Complete methylation + 21q22.3 71.9 0.81 695 44645451 44646145 CDS Transient receptor potential channel 7 (TRPC7)
#111 (NT_002835.3 1187382-1188869) Unmethylation — 21q22.3 75.8 0.79 488 44731346 44731833 —
#112 (NT_002835.3 1438369-1439902) Composite methylation + 21q22.3 64.9 0.85 534 44982314 44982847 Intron Chromosome 21 open reading frame 29 (C21orf29)
#113 (NT_002835.3 1441617-1443042) Unmethylation — 21q22.3 62.4 0.79 426 44985562 44985987 —
#114 (NT_002835.3 1533742-1535201) Unmethylation — 21q22.3 73.2 0.91 460 45077687 45078146 5′-UTR and CDS Ubiquitin-conjugating enzyme E2G2 (UBE2G2); homologous to yeast UBC7
#115 (NT_002835.3 1549573-1551858) Unmethylation — 21q22.3 74.6 0.93 1286 45093518 45094803 5′-UTR SMT3 (suppressor of mif two 3, yeast) homolog 1 (SMT3H1)
#116 (NT_002835.3 1604933-1607527) Unmethylation — 21q22.3 70.5 0.97 1595 45148878 45150472 5′-UTR and CDS Pituitary tumor-transforming 1 interacting protein (PTTG1IP)
#117 (NT_002835.3 1664660-1666157) Unmethylation — 21q22.3 78.9 0.74 498 45208605 45209102 Intron Prediction gene 54 (PRED54)
#118 (NT_002835.3 1671866-1673671) Unmethylation — 21q22.3 70.3 1.00 806 45215811 45216616 5′-UTR Chromosome 21 open reading frame 67 (C21orf67)
#119 (NT_002835.3 1680257-1681681) Complete methylation + 21q22.3 65.8 0.90 425 45224202 45224626 Intron Prediction gene 55 (PRED55)
#120 (NT_002835.3 1710450-1712127) Complete methylation + 21q22.3 72.7 1.07 678 45254395 45255072 —
#121 (NT_002835.3 1750441-1752578) Unmethylation — 21q22.3 75.4 0.81 1138 45294386 45295523 —
#122 (NT_002835.3 1806394-1808604) Unmethylation — 21q22.3 77.5 1.03 1211 45350339 45351549 5′-UTR Double-stranded RNA-specific adenosine deaminase 2 (ADAR2)
#123 (NT_002835.3 1865795-1867783) Complete methylation + 21q22.3 67.2 0.85 989 45409731 45410719 5′-UTR and CDS Double-stranded RNA-specific adenosine deaminase 2 (ADAR2)
#124 (NT_002835.3 2020037-2021768) Unmethylation — 21q22.3 75.5 0.79 732 45563914 45564645 KIAA0958; chromosome 21 open reading frame 80 (C21orf80)
#125 (NT_002835.3 2077997-2079517) Complete methylation + 21q22.3 54.7 0.77 521 45621843 45622363 Intron Prediction gene 59 (PRED59)
#126 (NT_002835.3 2112166-2114090) Complete methylation + 21q22.3 63.8 1.15 925 45656012 45656936 —
#127 (NT_002835.3 2136861-2139459) Unmethylation — 21q22.3 79.1 0.88 1599 45680707 45682305 5′-UTR and CDS Collagen type XVIII alpha 1 (COL18A1)
#128 (NT_002835.3 2274532-2276182) Incomplete methylation — 21q22.3 77.8 0.84 651 45818349 45818999 5′-UTR (exons 1a, 1c, and 1b) Reduced folate carrier (RFC1; SLC19A1)
#129 (NT_002835.3 2286418-2288635) Complete methylation + 21q22.3 75.0 0.79 1218 45830961 45832178 —
#130 (NT_002835.3 2322402-2323845) Composite methylation — 21q22.3 72.5 0.78 444 45866945 45867388 —
#131 (NT_002835.3 2364595-2366958) Complete methylation + 21q22.3 66.7 0.98 1364 45909214 45910577 —
#132 (NT_002835.3 2371534-2374424) Unmethylation — 21q22.3 76.3 0.89 1891 45918451 45920341 —
#133 (NT_002835.32475023-2477222) Complete methylation + 21q22.3 57.9 1.15 1200 46021940 46023139 —
#134 (NT_002835.3 2653007-2655508) Complete methylation + 21q22.3 54.8 1.25 1502 46199895 46201396 Intron Poly (rC)-binding protein 3 (PCBP3)
#135 (NT_002835.3 2716963-2718791) Complete methylation + 21q22.3 72.0 0.79 829 46263850 46264678 CDS Alpha-1 collagen type VI (COL6A1)
#136 (NT_002835.3 2732562-2734239) Complete methylation — 21q22.3 67.5 0.84 678 46279449 46280126 CDS Alpha-1 collagen type VI (COL6A1)
#137 (NT_002835.3 2735023-2736682) Complete methylation + 21q22.3 76.8 0.73 660 46281910 46282569 —
#138 (NT_002835.3 2827157-2828726) Unmethylation — 21q22.3 79.6 0.75 570 46374044 46374613 5′-UTR Alpha-2 collagen type VI (COL6A2)
#139 (NT_002835.3 2841396-2842933) Complete methylation — 21q22.3 68.5 0.81 538 46388283 46388820 CDS Alpha-2 collagen type VI (COL6A2)
#140 (NT_002835.3 2855101-2856552) Complete methylation — 21q22.3 63.7 0.91 452 46401988 46402439 CDS Alpha-2 collagen type VI (COL6A2)
#141 (NT_002835.3 2861362-2862966) Complete methylation — 21q22.3 69.4 0.86 605 46408249 46408854 CDS Alpha-2 collagen type VI-a′
#142 (NT_002835.3 2890249-2891697) Composite methylation — 21q22.3 70.8 0.77 449 46437137 46437585 CDS and 3′-UTR Similarity to Mus musculus adult male testis cDNA
#143 (NT_002835.3 2957438-2959877) Unmethylation — 21q22.3 73.6 0.75 1576 46504326 46505901 5′-UTR and CDS Lanosterol synthase (2,3-oxidosqualene-lanosterolcyclase) (LSS)
#144 (NT_002835.3 3014936-3016783) Unmethylation — 21q22.3 69.5 0.95 848 46561824 46562671 5′-UTR and CDS Minichromosome maintenance deficient 3 (S. cerevisiae)- associated protein (MCM3AP)
#145 (NT_002835.3 3052859-3055543) Unmethylation — 21q22.3 71.7 0.88 1955 46599747 46601701 5′-UTR and CDS Pericentrin 2 (kendrin) (PCNT2)
#146 (NT_002835.3 3132299-3134479) Complete methylation + 21q22.3 58.0 1.07 1181 46679187 46680367 Intron Pericentrin, kendrin
#147 (NT_002835.3 3187879-3189962) Unmethylation + 21q22.3 75.3 0.77 1280 46734767 46736046 —
#148 (NT_002835.3 3364581-3366420) Unmethylation — 21q22.3 70.8 0.83 840 46911470 46912309 5′-UTR HMT 1 (hnRNP methyltransferase, S. cerevisiae)-like 1
#149 (NT_002835.3 3396443-3398312)
Unmethylation
—
21q22.3
67.3
0.81
934
46943268
46944201
—

a The name in parenthesis for each CpG island indicates its symbol in URL (http://hgp.gsc.riken.go.jp/CGI/)

b The plus (+) and minus (–) indicate the presence and absence of tandem repeat sequences, respectively

c The GC % indicates the GC-content of each CpG island

d The Obs/exp indicates the ratio of observed and expected CpG frequency

e The start and end point of each CpG island are shown using nucleotide positions in the sequence of human chromosome 21q in UCSC genome browser (http://genome.ucsc.edu/)

f The 5′-UTR (5′-untranslated region), CDS (coding region) and 3′-UTR (3′-untranslated region) indicate the location of the CpG island in its flanking gene