Table 1.

Performance metrics


Metrica

Value

Confidence
Input Requirement (Total RNA) 100 ng n/a
Limit of Detectionb ∼0.13 pM 99%
Specificityc ∼1:250,000 99%
Precisiond ∼1.3-fold 95%
Dynamic Rangee ∼3.2 Logs n/a
Array-to-Array %CVf
<10%
n/a

a The median value of nine spike controls is given for each performance metric. All metrics listed derive from measurements made using two probe sequences per gene

b Limit of detection is determined by a negative control detection model (see Methods)

c Specificity is determined by dividing the number of molecules detected at the limit of detection by the number of molecules present in 1 μg of sample background. The average mammalian transcript length is estimated at 2000 nt

d Precision is the smallest change in concentration that can be detected with 95% confidence. Value given is the median across the dynamic range

e Dynamic range is defined by the ability to detect twofold changes in target concentration across the specified concentration range (see Methods)

f Array-to-array %CV is determined using a common population of all detectable bead-types across the 96 arrays of an array matrix