Table 1.

Duplicate Genes That Have Rapidly Diverged in Gene Expression

Protein 1
Protein 2
KA
KS
N expra
N divb
Rc
Function of protein 1
Function of protein 2
Gene pairs that have diverged in expression (presence or absence) in at least 50% of the tissues studied (in which at least one of the two duplicate genes is expressed)
    AAA02487 CAA36842 0.116 0.217 2 2 n/ad activator protein 2B transcription factor AP-2
    AAA02993 BAA00310 0.109 0.164 1 1 n/a cytochrome P450 PCN3 cytochrome P-450 HFLa
    AAA35658 BAA04619 0.093 0.201 7 6 0.19 chlordecone reductase unknown function
    AAA35781 AAC50056 0.079 0.115 25 25 0.13 DNA-binding protein RNA-binding protein
    AAA35827 AAA36051 0.165 0.188 25 18 0.20 IgG Fc fragment receptor precursor IgG Fc receptor β-Fc-γ-RII
    AAA35946 CAA46096 0.077 0.141 7 6 >0.5 human complement factor H serum protein
    AAA36014 AAA51831 0.034 0.162 2 1 n/a δ-5-δ-4 isomerase type II δ-5-δ-4-isomerase
    AAA36236 AAA59772 0.047 0.086 15 15 -0.15 lymphocyte antigen lymphocyte antigen
    AAA36444 AAA36445 0.029 0.088 4 4 n/a phospholipase D phospholipase D
    AAA36511 AAA52607 0.069 0.082 5 3 >0.5 β1-glycoprotein β1-glycoprotein precursor
    AAA36516 CAA35612 0.126 0.114 5 4 >0.5 β1-glycoprotein β1-glycoprotein
    AAA36793 CAA68415 0.078 0.189 2 1 n/a UDP-glucuronosyltransferase precursor
    AAA51718 AAC21581 0.068 0.057 14 7 -0.34 amelogenin Y amelogenin X
    AAA52576 CAA55364 0.007 0.073 2 1 n/a glycerol kinase glycerol kinase
    AAA59755 AAA59823 0.049 0.076 6 6 -0.34 HLA DQ-β MHC DQw1 β surface glycoprotein
    AAA60066 AAA60067 0.066 0.096 3 3 n/a platelet factor 4 platelet factor 4
    AAA63183 AAA63184 0.063 0.059 7 6 >0.5 cytokine gro-β cytokine gro-β
    AAA75171 AAA75172 0.165 0.201 9 9 0.14 cysteine protease cysteine protease
    AAA81368 CAA11262 0.075 0.111 11 10 0.47 zinc finger protein transcriptional repressor
    AAB21124 CAA43715 0.017 0.020 2 1 n/a p50-NF-κB homolog NF-κB subunit
    AAB01380 AAC50613 0.018 0.083 19 19 -0.10 NADP-dependent malic enzyme NADP-dependent malic enzyme
    AAB42011 CAA63427 0.095 0.105 5 <5 -0.91 MHC class I molecule MHC class I chain-related protein A
    AAB53424 CAA69164 0.115 0.108 2 2 n/a butyrophilin put. B7,3 molecule of CD80-CD86 family
    AAB53426 AAB53430 0.092 0.169 24 20 >0.5 butyrophilin butyrophilin
    AAB68615 CAA72414 0.045 0.086 2 2 n/a 8-hydroxyguanine glycosylase DNA glycosylase/AP lyase
    AAB86528 CAA75867 0.042 0.047 25 24 >0.5 apoptosis inhibitor apoptosis inhibitor homolog
    AAB87667 AAC99761 0.139 0.139 14 11 0.38 immunoglobulin-like receptor immunoglobulin-like receptor
    AAC50187 AAC50189 0.042 0.173 2 2 n/a α(1,3/1,4) fucosyltransferase α(1,3) fucosyltransferase
    AAC51146 AAD03159 0.154 0.166 7 6 0.44 NK-receptor killer cell inhibitory receptor
    AAC52104 AAD02195 0.057 0.236 25 22 >0.5 aflatoxin aldehyde reductase AFAR aflatoxin B1-aldehyde reductase; AFAR
    AAD02203 AAD03158 0.153 0.223 2 2 n/a immunoglobulin-like transcript 7 immunoglobulin-like transcript 10
    AAD02289 BAA24506 0.075 0.085 5 5 >0.5 paired-box transcription factor Pax-4
    BAA07512 BAA07513 0.084 0.160 1 1 n/a yeast PMS1 homolog yeast PMS1 homolog
    BAA11829 CAA43795 0.019 0.190 15 15 0.32 collagen binding protein 2 collagen-binding protein
    CAA04922 CAA04923 0.063 0.079 1 1 n/a NKG2C NKG2E
    CAA39460 CAA39462 0.174 0.133 3 3 n/a eosinophil derived neurotoxin eosinophil cationic protein
    CAA46987 CAA51545 0.033 0.052 23 21 >0.5 skeletal muscle C protein skeletal muscle C protein
    CAA57956 CAA76384 0.027 0.221 23 16 0.49 hair keratin acidic 3-II keratin, type I
Gene pairs with R < 0.5e
    AAA67367 CAA38201 0.008 0.174 25 <5 0.37 myosin regulatory light chain myosin regulatory light chain
    AAA98669 BAA08533 0.030 0.067 8 <5 -0.56 U2AFBPL U2AF1-RS2
    AAC97383 BAA31626 0.075 0.111 23 <5 0.26 guanine nucleotide factor unknown function
    BAA19516
CAA60130
0.059
0.082
9
<5
-0.66
homolog of the murine Llglh gene
homolog to Drosophila tumor suppressor gene

a N expr is the number of tissues studied in which at least one of the two duplicate genes is expressed

b N div is the number of tissues in which one gene is expressed and the other is not (i.e., the two genes have diverged in expression)

c R is the correlation coefficient between the expression levels of the two genes over the tissues studied

d n/a is not applicable because the number of tissues in which at least one of the duplicates is expressed was less than five

e Fourteen gene pairs with R < 0.5 have already been mentioned above and so are not included here