Table 1.

Genes and Predicted Protein Products From HSET to BTLII of the Cat MHC Class II Region

% aa sequence similarity
Gene
Functional/physiological properties/other name/structure
Size (bp)
Predicted protein size (aa)
No. of exons
Distance to next gene (bp)
Human
Mouse
Extended Class II Region
HSET Kinesin motor protein-related, kifc, KNSL2, kinesin-like protein 2 >13226 >657 >10 12643 91 83
RPS28 Component of S28 of ribosome 1861 103 2 46489 55 55
DAXX Fas binding protein, apoptosis through c-Jun 3197 748 7 1754 91 80
BING1 Zinc finger domain 1907 635 1 959 95 88
TAPASIN Ig superfamily, associate with class I antigen during peptide loading 11062 488 9 2207 85 75
RGL2 Rat guanine nucleotide dissociation factor 6658 664 15 3121 94 92
BING4 WD40 domain 7638 612 15 709 93 87
B3GALT4 β 1,3-galactosidase-4 1152 378 2 1000 86 81
RPS18 Component of S18 of ribosome, KE3 5011 152 6 438 100 100
ARE1 Yeast sac2 homolog, suppressor of actin mutant 2, Sacm21, coiled coil structure 15145 702 17 28038 99 93
TAT-SF1 HIV1 transcriptional elongation factor, pseudogene ND ND 1 ND ND ND
RING1 Ring finger protein, polycomb group protein 2351 307 6 4129 99 98
KE6 Steroid dehydrogenase-like protein (estradiol 17 β-dehydrogenase 8) ND 149 4 ND 61 60
KE4 Transmembrane protein with histidine-rich charge clusters 4516 193 4 858 83 82
RXRB Retinoid X receptor, β 5559 475 10 2515 100 97
COL11A2 Type 11 collagen α 2 28027 1624 60 7492 97 95
Classical Class II Region
DPB Class II antigen, β chain, pseudogene 22891 317 5 2597 60 ND
DPA Class II antigen, α chain, pseudogene 8678 235 5 5075 74 ND
X Unknown function 9161 205 2 10553 ND ND
DNA DOA, heterodime with DOB in pre-B cells, peptide loading for class II antigen at low PH 9622 250 5 15757 86 77
RING3 Nuclear-localized, serine-threonine kinase, frg-1 13809 1093 17 10773 98 95
DMA Nonclassical class II antigen, α chain, peptide loading for class II antigen 3926 260 5 9876 86 81
DMB Nonclassical class II antigen, β chain, heterodimer with DMA, peptide loading for class II antigen 9387 279 5 16548 82 70 (Mb1), 71 (Mb2)
V-ATPase Vacuolar ATPase, pseudogene 9952 229 4 21688 70 70
LINE1 Reverse transcriptase homolog 464 154 1 15606 59 48
LMP2 Proteosome subunit to cleave peptides for class I antigen 3057 196 5 2528 92 91
TAP1 Transporter for antigen processing 7279 713 11 1822 82 75
LMP7 Proteosome subunit to cleave peptides for class I antigen 2875 276 5 2591 82 85
TAP2 Transporter for antigen processing 9852 702 11 3451 79 77
LINE1 Reverse transcriptase homolog 1039 198 2 5980 50 45
DOB Nonclassical class II antigen, β chain, H2-IAB2 in mouse 18247 209 4 1119 72 67
LINE1 Reverse transcriptase homolog 18237 222 4 14603 70 68
DRB4 Class II antigen, β chain 12470 266 5 33292 81 (DRB3) 78 (Eb1)
GAPDH Glycerol aldehyde phosphodehydrase, pseudogene ND ND ND ND ND ND
DRB1 Class II antigen, β chain 10009 266 5 14668 81 (DRB3) 78 (Eb1)
DRA1 Class II antigen, α chain 2684 254 5 40740 91 81
SURF3 L7a ribosomal protein, pseudogene ND ND 1 inside intron 1 of DRB2 ND ND
DRB2 Class II antigen, β chain, intron 1 & exon 2 gene fragment, pseudogene ND 89 1 ND ND ND
DRB3 Class II antigen, β chain 9680 294 5 10790 81 (DRB3) 80 (Eb1)
X Unknown function 179 266 1 2666 ND ND
DRA2 Class II antigen α chain 2684 254 5 24414 91 81
X Unknown function 176 58 1 6120 ND ND
DRA3 Class II antigen α chain 3132 254 5 19743 92 83
BTLII
Butyrophilin-like gene, immunoglobulin superfamily
>26700
>392
>6
ND
75
65 (NG9)