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Table 1.

A Priori Unidentifiable Parameters Grouped by Biological Function, for the Three Perturbations

Biological function (total params.)	Single step	Single pulse	Double pulse
Protein monomer degradation (10)	8 (6)^a	4 (2)^a	4 (2)^a
Transcript degradation (10)	7	5	5
Translation (10)	9 (7)^a	5 (3)^a	6 (4)^a
Unidimerization and dimer deg. (21)	13 (6)^b	10 (3)^b	11 (4)^b
Promoter un/binding (20)	12 (2)^b	13 (3)^b	13 (3)^b
Transcription (26)	2	0	0
Total (97)	51 (30)^c (23)^d	37 (16)^c (11)^d	39 (18)^c (13)^d

a The number of unidentifiable parameters that would remain if the insensible parameters (see text) were removed from the model.

b The number of unidentifiable parameters that would remain if the equilibrium approximation was made for the appropriate parameters.

c The total remaining unidentifiable parameters if the insensible parameters were removed and the equilibrium assumption was applied where appropriate.

d The total remaining unidentifiable parameters if mRNA half-lives were measured in addition to application of the equilibrium assumption and removal of insensible parameters.