Markup | Genome Research

Table 8.

Expression Changes Specific for Ciprofloxacin or Novobiocin

No.		Gene product		Fold change mRNA
No.		Gene product		Cipro 10 min	Novo 10 min	Cipro 60 min	Novo 60 min
Specific for Ciprofloxacin
hi0020	2-Oxoglutarate/malate translocator	−2.0	NC	−1.7	NC
hl1135	Phospho-N-acetylmuramoyl-pentapeptide-transferase	−2.2	NC	−2.1	NC
hl0070	DNA repair protein RecN	4.8	NC	13.0	NC
hi0162	Conserved hypothetical protein	1.5	NC	1.8	NC
hi0250	Single-stranded DNA binding protein	2.5	NC	2.9	NC
hi0312	Holliday junction DNA helicase	1.8	NC	3.3	NC
hi0600	Recombinase RecA	2.7	NC	2.0	−1.8
hi1159	Conserved hypothetical protein	1.5	−3.5	3.0	−1.8
hi1188	DNA helicase II	1.9	NC	4.5	NC
hi1546	ImpA protein	4.8	NC	15.0	NC
Specific for Novobiocin
hi0343	Conserved hypothetical protein	NC	−2.7	NC	−2.5
hi0365	Conserved hypothetical protein	NC	−4.4	NC	−2.6
hi0434	Transformation protein	NC	−7.1	NC	−4.3
hi0440	Penicillin-binding protein	NC	−2.2	NC	−1.1
hi0498	Spermidine/putrescine-binding periplasmic protein precursor	NC	−2.4	NC	−1.4
hi0558	Glucose-6-phosphate 1-dehydrogenase	NC	−2.3	NC	−1.4
hi0838	Small protein a	NC	−2.8	NC	−1.7
hi0898	Multidrug resistance protein	NC	−2.5	NC	−1.5
hi0983	Conserved hypothetical protein	NC	−2.9	NC	−1.9
hi1151	Conserved hypothetical protein	NC	−3.9	NC	−2.8
h1159	Conserved hypothetical protein	NC	−3.5	NC	−1.8
hi1163	D-Lactate dehydrogenase	NC	−3.2	3.6	−2.5
hi1190	Conserved hypothetical protein	NC	−4.1	NC	−9.8
hi1191	Conserved hypothetical protein	NC	−11.5	NC	−17.3
hi1388	Anthranilate synthase component ii	NC	−3.3	NC	0.3
hi1585	Acetolactate synthase iii large chain	NC	−2.5	NC	−1.4
hi0037	Rod shape-determining protein	NC	2.0	1.7	1.8
hi0690	Glycerol uptake facilitator protein	NC	1.6	NC	1.2
hi0691	Glycerol kinase	NC	1.7	NC	1.4
hi0971	Acetyl-con carboxylase, biotin carboxyl carrier protein	NC	1.7	NC	1.8
hi1308	Dihydrodipicolinate reductase	NC	2.0	NC	1.9
hi1623	Mercury resistance regulatory protein	NC	3.2	NC	3.2
hi1659	Ribonucleoside-diphosphate reductase, alpha chain	NC	1.7	3.6	2.0
hi1660	Ribonucleoside diphosphate reductase, beta chain	NC	2.3	NC	2.2
hi1717	Hypothetical protein	NC	1.8	NC	1.9