Table 7.

False Positives for oncogenesis:Missing Annotations

Symbol (GenBank accession number) Gene name Molecular function Comment Reference (PMID)
CCNG1(R45687)Cyclin G1CDK kinase regulatorp53 target11327114
CDKN1C (R81336)Cyclin-dependent kinase inhibitor 1CCyclin-dependent protein kinase inhibitorTumor suppressor7729684
CAT(W89002)CatalaseOxidoreductaseTumor progression8513880, 11597785
ALDH3A2 (H63779)Aldehyde dehydrogenase 10Aldehyde dehydrogenaseTumor progression92393980
ADD3 (AA054129)Adducin 3 (gamma)Membrane-cytoskeleton-associated proteinTumor progression9607561
TFDP2 (W46792)Transcription factor Dp-2 (E2F dimerization partner 2)Transcription cofactorCell cycle regulation7784053
ATRX(N22858)α Thalassemia/mental retardation syndromeDNA helicaseTranscription and DNA repair10362365, 10630641
EPS15 (N78949)Epidermal growth factor receptor pathway substrate 15Kinase substrateGrowth regulation93361014
EGR1 (H27557)Early growth response 1Transcription factorTumor suppressor9109500
NR4A2 (N22386)Nuclear receptor subfam 4, group A, m2 (Nurr1, Not)Ligand-dependent nuclear receptorProto-oncogene9592180
NR4A3(W42606)Nuclear receptor subfam 4, group A, m 3 (Nor1)Ligand-dependent nuclear receptorProto-oncogene9592180
COPEB(AA055585)Core promotor element-binding proteinTranscription factorProto-oncogene9268646

[i] This table shows genes classified but not annotated with the biological process oncogenesis (e.g., false positives foroncogenesis), where information could be found in the literature confirming that the classification was correct and thus represented knowledge that was missed during annotation (missing annotation).