Table 4.

Statistical Evaluation of Mobility Shift

No. Mobility shift[i] No. Mobility shift[i]
sense antisense sense antisense
gyrA hFIX exon 7
 1−8.6923.511−11.62−0.93
 2−11.21−2.9224.532.49
 327.161.963126.41166.66
 40.18[ii] 11.184−12.58−2.08
 553.21−5.915133.61143.92
 677.6954.97
 747.9056.54
 867.0371.18hFIX exon 8
 9−50.63−24.51
10−3.80−1.95111.1352.11
11−12.080.9923.562.00
12−4.83−1.953−55.12−3.00
13−3.8014.11415.4332.93
14−0.81[ii] 0.01[ii] 5−41.01−57.68[iii]
15−10.05−2.896−35.14−57.34
161.224.09
172.204.02
1872.5879.07
1978.0175.30
2093.4479.23
2128.890.99
228.1512.37
231.19[ii] 3.03

[i] Mobility shift is defined as a difference between data point of mutant peak and averaged data point of normal peak. The standard deviations of normal DNAs are gyrA sense strand, 0.40; gyrA antisense strand, 0.01; hFIX exon 7 sense strand, 0.46; hFIX exon 7 antisense strand, 0.10; hFIX exon 8 sense strand, 0.40; hFIX exon 8 antisense strand, 0.63.

[ii] False negative (within 3× s.d. of normal DNA)

[iii] A minor peak was observed at 0.04, presumably attributable to an isoconformer.