Markup | Genome Research

Table 4.

Connectivity of Metabolites in Saccharomyces cerevisiae, Escherichia coli, Haemophilus influenzae, and Helicobacter pylori

S. cerevisiae		E. coli		H. influenzae		H. pylori
metabolite		connectivity		metabolite		connectivity		metabolite		connectivity		metabolite	connectivity
metabolite		absolute	relative (%)	metabolite		absolute	relative (%)	metabolite		absolute	relative (%)	metabolite	absolute	relative (%)
Proton	229	5.0	ATP	160	6.1	ATP	114	6.5	ATP	79	5.7
ATP	188	4.1	Phosphate	140	5.3	Phosphate	102	5.8	ADP	65	4.7
ADP	146	3.2	ADP	137	5.2	ADP	101	5.8	Phosphate	60	4.3
Phosphate	131	2.9	Proton	86	3.3	Proton	77	4.4	Proton	47	3.4
CO₂	90	2.0	CO₂	63	2.4	CO₂	40	2.3	Diphosphate	38	2.7
NADP	86	1.9	Diphosphate	56	2.1	Diphosphate	40	2.3	CO₂	36	2.6
NADPH	78	1.7	Pyruvate	53	2.0	NADP	31	1.8	NADP	34	2.4
Diphosphate	81	1.8	Glutamate	48	1.8	NADPH	30	1.7	NADPH	33	2.4
NAD	78	1.7	NAD	48	1.8	Glutamate	30	1.7	Glutamate	23	1.7
NADH	65	1.4	NADH	43	1.6	NAD	24	1.4	NH₃	19	1.4
Glutamate	68	1.5	NADP	41	1.6	Pyruvate	22	1.3	Pyruvate	18	1.3
NH₃	56	1.2	NH₃	41	1.6	NH₃	22	1.3	COA	18	1.3

[i] (Absolute) Connectivity is defined as the number of occurrences of a metabolite in any of the reactions of the reconstructed metabolic networks. The relative connectivity has been calculated on the basis of the summed frequency of all metabolites in the reconstructed metabolic networks, which is 4551, 2637, 1753, and 1389 in S. cerevisiae, E. coli, H. influenzae, and H. pylori, respectively.