Cluster 0 is Enriched for Supercoiling-Dependent Gene Regulation
| Gene | Product |
| acnA | Aconitate hydrase 1 |
| b1664 | Possible enzyme |
| b1724 | Orf, hypothetical protein |
| b2809 | Orf, hypothetical protein |
| bax | Putative ATP-binding protein |
| btuE | Vitamin B12 transport |
| dps | Global regulator, starvation conditions |
| gcd | Glucose dehydrogenase |
| grxB | Glutaredoxin 2 |
| nlpD | Lipoprotein |
| osmE | Activator of ntrLgene |
| otsA | Trehalose-6-phosphate synthase |
| otsB | Trehalose-6-phosphate phosphatase, biosynthetic |
| poxB | Pyruvate oxidase |
| proV | ATP-binding component of transport system for glycine, betaine, and proline |
| proW | High-affinity transport system for glycine, betaine, and proline |
| proX | High-affinity transport system for glycine, betaine, and proline |
| rpoS | RNA polymerase, sigma S (sigma38) factor; synthesis of many growth phase-related proteins |
| sugE | Suppresses groEL, may be chaperone |
| tktB | Transketolase 2 isozyme |
| wrbA | Trp repressor binding protein; affects association of trp repressor and operator |
| yacK | Orf, hypothetical protein |
| ybaL | Putative transport protein |
| ybaY | Glycoprotein/polysaccharide metabolism |
| ybeL | Putative alpha helical protein |
| ygaM | Orf, hypothetical protein |
| yggB | Putative transport protein |
| ykfE | Orf, hypothetical protein |
| ynhG | Orf, hypothetical protein |
| yrbL | Orf, hypothetical protein |
[i] Thirty of 61 genes in cluster 0 have scores of 8 or better using the metric described in Fig. 3A.