Markup | Genome Research

Table 4.

Conserved LGR Hinge Sequences

LGR4–6 consensus	`YAYQCC`	`GXFKPCEX`
rk	`YAYHCC`	`GPFLPCAD`
LGR4	`YAYQCC`	`GAFKPCEY`
LGR5	`YAYQCC`	`GPFKPCEH`
FEX	`SAYQCC`	`GPFKPCEH`
FSHR/LSHR/TSHR consensus	`YPSHCC`	`DXFNPCED`
Fsh	`HSFHCC`	`NDLNPCED`
NLGR	`YPHHCC`	`DALNPCEN`
FSHR_human	`YPSHCC`	`DAFNPCED`
LSHR_human	`YPSHCC`	`DAFNPCED`
TSHR_human	`YPSHCC`	`DEFNPCED`
ALGR	`NGFLCC`	`DAFHPCED`
LGR7 consensus	`XZXZCX`	`DGZSSXXX`
CG4187	`NVRVCD`	`DGISSKLH`
CG5042	`RFFYCS`	`DGVSSFQD`
LGR7	`KFQYCG`	`DGISSLEN`
SLGR	`SYRFCC`	`DEFSSCED`
LDL receptor motif
CG4187[ii]	`NCDGSVDCDDASDEVNC`
CG5042	`CVPRRQMCDSRNDCADSSDENPVEC`

[i] The consensus hinge sequences for LGR4–6 and FSHR/LSHR/TSHR were described by Hsu et al. (2000). The consensus hinge sequences for LGR7 are based on a ClustalX alignment of these four proteins.

[ii] This sequence is truncated N-terminally, presumably due to missing sequence at the N-terminal end of the annotation.