Superfamilies With the Same Function in Single- and Multi-Domain Proteins as Determined from Their Keyword Combination or First Three Components of Their EC Numbers
| Sfam | Function | Single-domain proteins | Multi-domain proteins | ||
| SWISS-PROT ID | SWISS-PROT function | SWISS-PROT ID | SWISS-PROT function | ||
| 1.81.1 | E3.2.1 | GUNY_ERWCH | Endoglucanase (3.2.1.4) | AMYG_NEUCR | Glucoamylase Precursor (3.2.1.3) |
| 2.66.2 | E3.5.1 | URE2_YERPS | Urease Beta (3.5.1.5) | URE1_HELPY | Urease Alpha Subunit (3.5.1.5) |
| 3.17.2 | E6.3.5 | NADE_MYCPN | NAD(+) Synthetase (6.3.5.1) | GUAA_YEAST | GMP Synthase (6.3.5.2) |
| 3.37.1 | E3.1.3 | PTP2_NPVOP | Protein-Tyrosine Phosphatase 2 (3.1.3.48) | PTNB_RAT | Protein-Tyrosine Phosphatase (3.1.3.48) |
| 3.67.1 | E4.2.1 | TRPB_VIBPA | Tryptophan Synthase (4.2.1.20) | TRP_YEAST | Tryptophan Synthase (4.2.1.20) |
| 4.19.1 | E5.2.1 | FKB1_METJA | PeptidylprolylCis-Trans Isomerase (5.2.1.8) | FKB7_WHEAT | 70 Kd Peptidylprolyl Isomerase (5.2.1.8) |
| 4.2.1 | E3.2.1 | LYCV_BPP2 | Lysozyme (3.2.1.17) | CHIX_PEA | Endochitinase Precursor (3.2.1.14) |
| 4.29.1 | 85# | RS5_ACYKS | 30s Ribosomal Protein S5 | RS5_TREPA | 30s Ribosomal Protein S5 |
| 4.52.1 | E3.4.24 | SNPA_STRCS | Extracellular Neutral Protease (3.4.24.–) | BMPH_STRPU | Collagenase 3 Precursor (3.4.24.–) |
| 4.6.1 | E3.5.1 | URE3_YERPS | Urease Gamma (3.5.1.5) | URE1_HELPY | Urease Alpha Subunit (3.5.1.5) |
| 5.10.1 | E2.7.7 | KANU_STAAU | Kanamycin Nucleotidyltransferase (2.7.7.–) | DPOB_XENLA | Dna Polymerase Beta (2.7.7.7) |
| 5.4.1 | 161# | AMPH_ECOLI | Penicillin-binding Protein Amph | PBPX_STRPN | Penicillin-binding Protein 3x Pbp2x |