Table 4.

Changes at the Protein Level after Addition of 125 ng/mL of Novobiocin

No. Gene product Fold change protein (mRNA)
10 min 30 min 60 min
hi0048Oxidoreductase−3.1 (NC)−3.5 (NC)−1.7 (NC)
hi0089Aspartokinase I/homoserine  dehydrogenase I−2.6 (−3.4)−1.3 (NC)−2.0 (−2.0)
hi0119Adhesin B precursor−261.8 (NC)−12.8 (−2.8)−34.1 (−2.7)
hi0124Inorganic pyrophosphatase−2.1 (1.2)−3.3 (NC)−5.4 (NC)
hi0504Periplasmic ribose-binding protein−1.8 (−2.2)−2.5 (−3.9)−3.5 (−1.9)
hi0524Fructose-bisphosphate aldolase2.0 (1.8)2.1 (1.6)1.0 (1.9)
hi0525Phosphoglycerate kinase−2.0 (2.2)−2.1 (2.1)−2.9 (2.0)
hi0542Heat shock protein GroES−1.9 (−2.3)−4.4 (−4.6)−3.5 (−3.7)
hi0544Ribosomal protein L9−3.5 (−1.5)−2.0 (−1.7)−3.6 (NC)
hi0547Ribosomal protein S6−4.2 (NC)−2.1 (NC)−2.7 (NC)
hi05536-Phosphogluconate dehydrogenase,  decarboxylating−5.5 (NC)−4.4 (NC)−3.2 (NC)
hi0574Conserved hypothetical protein−3.8 (−2.1)−3.8 (−2.9)−4.0 (−2.3)
hi0808Ribosome releasing factor−4.7 (−4.5)−4.4 (−5.4)−4.7 (−4.9)
hi0846Disulfide oxidoreductase−2.6 (NC)−2.0 (−1.9)−2.4 (−2.1)
hi0913Ribosomal protein S2−2.3 (NC)−3.8 (−2.4)−5.2 (−2.2)
hi0914Elongation factor EF-Ts−4.2 (NC)−5.5 (−3.0)−2.9 (−2.6)
hi0927Glycyl-tRNA synthetase alpha chain2.5 (NC)2.9 (1.5)−1.2 (1.6)
hi1228Uracil phosphoribosyltransferase−3.0 (−2.0)−3.2 (−2.2)−3.4 (−2.0)
hi1507Hypothetical protein−4.1 (1.3)−3.2 (−3.5)−2.9 (−3.2)
hi1647Conserved hypothetical protein−2.0 (−2.3)−1.8 (−1.8)−2.3 (−1.6)
hi1734Enoyl-reductase−8.8 (−2.6)−7.2 (−2.6)−6.2 (−2.1)