Table 3.

Human–Horse Comparative Gene Map Using Synteny, Linkage and in Situ Hybridization (127 Genes)

Hsa[i] Locus Locus name ECA [ii] Method[iii] Bta [iv] Mmu [v] Fca [vi] Ssc [vii]
1p36.2 NPPA natriuretic peptide precursor, A2S164——
1p36.2–p36.13 PGD phosphogluconate dehydrogenase 2p12 I,L164C16q2.2 q2.5
1p31 PGM1 phosphoglucomutase 15L35C16
1p13.1 NGFB nerve growth factor, β5S33—4q1.6–q2.3
1q21 GBA glucosidase,β, acid5S33—4
1q23–q25.1 AT3 antithrombin III5S161——
1q31 LAMC1 laminin, C15S161——
2p25 ODC1 ornithine decarboxylase 15q27 I—12——
2p21 CAD carbamoylphosphate synthetase 15q25 I—1——
2p21 SPTBN1 spectrin, β, nonerythrocytic 115S—11——
2q14 IL1B interleukin 1, β15S223q1.1–q1.4
2q12–q14 PAX8 human paired domain15S—2——
2q21 LCT lactase-phlorizin hydrolase 15q21 I—1—15q1.3
2q32.1 MSTN myostatin18S21——
2q24–q32 CHRNA cholinergic receptor, nicotin, α18S22——
2q31–q32 NEB nebulin18S22——
2q33–34 CHRNG cholinergic receptor, nicotin, γ[6]S21——
2q34 FN1 fibronectin 1[6]S21——
3p24.3–24.2 RARB retinoic acid receptor, β16S—14——
3p21.33 GLB1 galactosidase, β, 116S—9B3—
3q21–q24 RHO rhodopsin16S226——
3q21 TF transferrin 16q23 S19—13q3.1
3q21–q23 LTF lactotransferrin 16q I229——
3q21–q24 CP ceruloplasmin16S19—13q3.2–q3.3
3q28 SST somatostatin19S116——
4p16.3 FGFR3 fibroblast growth factor receptor3S65——
4q11–q13 ALB albumin 3q14 S,I65—8q1.2
4q12 GC group specific component3L65——
4q12 KIT mast cell growth factor receptor 3q21 L,I65B18p12–p21
4q12 PDGFRA platelet derived growth factor A 3q21 I, L65—8p12
4q22 ADH2 alcohol dehydrogenase 23S63——
4q22 ADH3 alcohol dehydrogenase 33S63—8
4q26–q27 IL2 interleukin 22S173B18
4q28 FGG fibrinogen, γ polyp2S173—8
5p13 IL7R interleukin receptor 721S—15——
5p13–p12 GHR growth hormone receptor21S2015—16q1.3–q1.4
5p14 C9 complement component 921S1——16q14
5q11–q12 CTLA3 cytotoxic T-1 assoc serine es 321S—13——
5q13 HEXB hexoseaminidase b14S2013——
5q21–q23 CAMK4 calmodulin depend. Prot. kinase 414S—18——
5q31.1 CSF2 colony stimulating factor 214S711—5
5q31–q32 SPARC secreted pro, ac, cyst-rich14S711——
5q32–34 ADRB2 adrenergic receptor, β214S718——
5q33.2–q33.3 CSF1R colony stimulating factor 1 receptor14S718A1—
6pter–p21.1 CLPS colipase20S—17—7
6p25–p24 F13 coagulation factor 13, A 20q13 L,I23——4
6p21.2 PIM1 Pim-1 oncogene 20q24 I—17B2—
6p21 HLA major histocompatibility complex20qL,I,S2317B27
6p21.3 CYP21 cytochrome P45020L2317—7
6p21.3 C4 complement component 420L2317—7
6p21.3 TNFA tumor necrosis factor, A20S2317—7p1.1–q1.1
6q13 COL9A1 collagen type IX, α-1 20q24 S—1——
6q24–p23 EDN1 endothelin 120S—13—7p1.3–p1.2
6q12 ME1 malic enzyme 10q12 S,I99B21
6q21.1–q23 CGA glycoprotein hormone, α chain10S94—1
6q21–q22.3 COL10A1 collagen, type X, α 110S—10——
6q25.1 ESR estrogen receptor 31q15 S96—1p2.5–p2.4
6q26 PLG plasminogen31S—17——
7p15–p14 TCRG T-cell receptor, γ subunit4S413A2—
7q11.2 ELN elastin13S255——
7q11.23–q21 GUSB glucuronidase, β13S255E3—
7q31.3 LEP leptin4S46—18
7q36 EN2 Engrailed 24S—5——
8q11 DNAPK DNA protein kinase, catalytic sub. 9p12 S—16——
8q24 TG thyroglobulin9S1415——
9p22 IFNA1 interferon, α-123S84—1
9p21 IFNB1 interferon, β-123S84—1
9p13 CNTFR ciliary neurotrophic factor receptor23S8q214——
9q31 TXN thioredoxin25S84——
9q33 GRP78 glucose-regulated protein25S112—1q2.12q2.13
10p13 VIM vimentin29S132—10
11p15.3–p15.1 PTH parathyroid hormone7S157—2
11p15.5 HBB hemoglobin β7S157D1—
11p15 TUB Tubby7S—7——
11p15.5 IGF2 insulin-like growth factor 2 12q14 S,I297——
11q12 CD20 CD20 antigen12S—19——
11cen-q13 ADRBK1 adrenergic receptor β kinase 112S—19——
11q22 PR progesterone receptor 7p16 I—9——
11q23.3 THY1 Thy-1 T-cell surface antigen7S159——
11q23 DRD2 dopamine receptor D27S—9—
12p12.2–p12.1 LDHB lactate dehydrogenase B[28]S56B45 q12
12q13.3 PFKM phosphofructokinase m[6]S5———
12q21 PEPB peptidase B[28]S510B45
12q22–q24.1 IGF1 insulin-like growth factor 1[28]S510—5q2.5
12q24 IFNG interferon γ[6]S510—5p1.1–q1.1
12q24.2 TCF1 transcription factor 1[8]S—5——
13q14.1–q14.2 RB1 retinoblastoma17S1214——
14q11 MYH6 myosin, heavy 61S—14——
14q11.2 CHY Chymase, mast cell1S—11——
14q13.1 NP nucleoside phosphorylase 1q26 S,I1014B37q2.1–q2.2
14q32.1 PI/AAT protease inhibitor/AAT 24q15 L,I712—7q2.4–q2.6
15q22–qter MPI mannose phosphate isomerase1S219B37
15q22–qter CYP1A2 cytochrome P450, subf. I, polyp. 21S—9——
15q25–q26 IGF1R insulin-1 growth factor 1 receptor1S217—1q1.7–q1.2
15q26.1 IDH2 isocitrate dehydrogenase 21S—7B3—
15q26.1 FES feline sarcoma virus homologue1S217B3—
16pter–p13.3 HBA hemoglobin A 13q I,L—11——
16p24.3 MC1R melanocortin receptor 3p12 L,S,I188——
16q13–q22.1 CES1 carboxylesterase3L—8——
16q21 GOT2 glutamate oxaloact. transam., mito 3p15 I,L—8——
16q22.1 HP haptoglobin3L188——
17q11.2 EVI2A ecotropic viral integration site2A11S—11——
17q11.2 NF1 neurofibromatosis 111S1911——
17q21 MYL4 myosin, light chain 411S1911
17q22–q24 GH growth hormone11S1911—12p1.2–p1.5
17q23.1–q25.3 HYPP hyperkalemic periodic paralysis11S—11——
17q25 P4HB prolyl-4 hydroxylase β11S1911——
18p11.32 TS thymidylate synthetase[8]S245——
19p13.3–p13.2 C3 complement component 3 7pter I,S—17—2p17–p14
19cen–q13.2 A1BG β globulin, A110L————
19q13.1 GPI glucose phosphate isomerase 10pter I187—6q12
19q13 CRC calcium release channel 10pter I18——6q12
19q13 CKM creatine kinase, muscle10S–7——
20pterp12 PRNP prion protein22S132——
20q11.2 GHRH growth hormone releasing hormone22S132——
20q11.2 ASP agouti signaling protein 22q15 S,I—2——
20q13.11 ADA adenosine deaminase22S132A3—
20q13.2 GNAS1 guanine nucleotide-binding protein22S132——
21q22.3 MX1 myxovirus resistance 26q17 I116—13
21q22.3 ETS2 avian erythroblastosis virus onc. 2 26q17 I,S116C2—
22q13.31–qter ARSA arylsulfatase A[28]S—15——
22q13.1 CYP2D cytochrome P450, subfamily IID[28]S515——
Xp11.21 ALAS2 anemia, hereditary sideroblasticXS—X——
Xq27.1–q27.2 F9 coagulation factor 9XSXXXX
Xq28 G6PD glucose 6 phosphate dehydrogenaseXSXXXX
Xq28 BGN biglycanXS—X——
Xq28 F18 factor 18 Xq29 S,I————

[i] Data retrieved from Online Mendelian Inheritance in Man (OMIM), Johns Hopkins University, Baltimore, MD (March 1999). Full references are available at http://www3.ncbi.nlm.nih.gov/omim/.

[ii] ECA assignment as in Shiue et al. (1999). In bold, physically assigned markers.

[iii] Method: (I) In situ hybridization; (L) linkage; (S) synteny. Full references available at http://www.vgl.ucdavis.edu/horse.

[iv] Data retrieved from Bovmap Database, INRA, Laboratoire de Génétique Biochimique et de Cytogénétique de Jouy-en-Josas (March 1999). Full references are available at http://locus.jouy.inra.fr/cgi-bin/bovmap/intro.pl. and The Cattle Mapping Database (ARKDB), Roslin Institute, UK (March 1999). Full references available at http://www.ri.bbsrc.ac.uk/cgi-bin/arkdb/browsers/browser.sh?species=cattle

[v] Data retrieved from Mouse Genome Informatics (MGI) Resource, Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, Maine (March 1999). Full references are available at http://www.informatics.jax.org/.

[vi] Data retrieved from O'brien et al. (1997b).

[vii] Data retrieved from PiGBASE, Roslin Institute, Edinburgh, UK (May 1998). Full references are available at http://www.ri.bbsrc.ac.uk/pigmap/pigbase/pigbase.html.