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Table 3.

Detection of Allelic Association from DNA Pools

Locus		Associated allele (bp)		Direct counts		Pool estimates
Locus		Associated allele (bp)		T	U	χ²	Pvalue[ii]	T	U	z	Pvalue[ii]
D13S792	287	30	12	13.0	<0.001	0.68	0.34	3.53	0.001
D13S317	191	40	18	18.6	<0.001	0.83	0.37	4.88	<0.001
D13S921	214	36	14	16.7	<0.001	0.56	0.16	4.33	<0.001
D13S790	183	30	9	17.8	<0.001	0.66	0.21	4.72	<0.001
D13S764	314	30	14	10.7	0.004	0.64	0.22	4.41	<0.001
GATA8G07	197	31	23	2.2	N.S.	0.64	0.42	2.3	N.S.
D13S628	250	29	13	10.1	0.007	0.46	0.32	1.49	N.S.

[i] Seven 13q genetic markers near the HSCR susceptibility locus were used to assess linkage disequilibrium by direct genotyping and from quantitation in DNA pools. The statistical significance (P value) of differences in allele counts/frequencies on transmitted (T) vs. untransmitted (U) chromosomes in Mennonites segregating HSCR were assessed either by a χ² or a normal deviate test.

[ii] (N.S.) Not significant.