Table 3.

Number of Families Required to Detect Linkage Disequilibrium for Sibships with Parents for Four Genetic Models Using Pooling

r = 1 r = 2 r = 3 r = 4 Parent affected r = 1
Dominant
 p = 0.05314985137186
 p= 0.202241179697205
 p = 0.702,9132,2222,2692,6073,179
Recessive
 p= 0.0538,9097,0711,84759936,443
 p = 0.209722419552885
 p = 0.70199122113127271
Multiplic.
 p= 0.051,251448218123918
 p = 0.2041717310171378
 p = 0.70451265215202559
Additive
 p = 0.0573425212576497
 p = 0.2033315210180302
 p = 0.70686411330299816

[i] Significance level α = 5 × 10−8; power 1 − β = 0.80.

[ii] Dominant model: f 2 = f 1 = 4; recessive model: f 2 = 4, f 1 = 1; multiplicative model: f 2 = 4,f 1 = 2; additive model: f 2 = 4, f 1 = 2.5.

[iii] (r) Number of affected sibs.