Effects of the Mom1 and Mom2 Loci on the Incidence of Colon Polyps in N2 Offspring from the B6 × D2B6F1ApcMin and D2 × D2B6F1ApcMin Backcrossesa
| Genotypes of B6 × D2B6F1 Apc Min N2 offspring | Mom1 S /Mom1 S | Mom1 R /Mom1 S | pvalues |
| Mom2+/Mom2+ | 71.4% (5/7) | 37.5% (3/8) | p= 0.3147 |
| Mom2R/Mom2+ | 8.6% (3/35) | 3.4% (1/29) | p= 0.6198 |
| p values | p = 0.0012 | p = 0.0256 |
| Genotypes of D2 × D2B6F1 Apc Min N2 offspring | Mom1 R /Mom1 S | Mom1 R /Mom1 R | Total |
| Mom2+/Mom2+ | 66.7% (2/3) | 50.0% (1/2) | 60.0% (3/5) |
| Mom2R/Mom2+ | 0.0% (0/9) | 14.2% (1/7) | 6.3% (1/16) |
| pvalue | p = 0.0276 |
[i] a N2 progeny of D2B6F1ApcMin parents #5, #6, and #7 from Table 1 were classified according to strain background as well as genotype and phenotype at the Mom1 and Mom2 loci, respectively. The % of mice within each class is given. The numbers in parentheses show the actual number of mice with ≥1 colon polyp over the total number of mice in each class. P values were determined by the Fisher's exact test.