Table 3.

Portion of the List of the 330 Tags with Statistically Significant Differences Between Normal and Ts 65 Dn Male Drain SAGE Libraries

TAG sequence Ts65Dn Normal P GenBank match
TCCCCGCACA2260.0000No match
AAATTATTGG110590.0000Proteolipid protein (myeline)
GCCCCCCTCT104540.0000No match
TCCCCGACAT9380.0000No match
TTGGTGAAGG19520.0001Prothymosin β-4
GACTGAATCT12390.0001Multiple matches
CGCCCGCCCG65300.0002Map1b
ATTTTCGAGG34100.0002ATPase, Na+K+ transporting β 1 polypeptide, Atp1b1
AATTCGCGGA861440.0002No match
TCCCCGTACG8310.0002No match
GAAAGTTGGC95530.0002Apolipoprotein D
TCTCCAGGCG38770.0003Clusterin
CTGCTATCCG9320.0003Ribosomal protein L5, 3′ end
AACGGGAGGT48200.0003Scgn10 like-protein
CAGCTCTGCC701190.0004ESTs, weakly similar to NEUROGRANIN (Rattus norvegicus)
GACAACGCCA17440.0004ESTs, highly similar to ATP SYNTHASE γ CHAIN, MITOCHONDRIAL (R. norvegicus)
GTGACCTGGC1691150.0004Prostaglandin D2 synthase (21 kD, brain)
AGGACAAATA102620.0007Biotinidase
TCCCCGTAAT2160.0007No match
CGCGCTCTCT2990.0008No match
CTGCTGGTGG30100.0009GTP-binding protein associated protein 1
GCCATCCCGG1310.0009No match
CAGGTGAGCC1520.0010No match
CGCAGTCCCC0100.0010No match
TCGGCGTGGA0100.0010No match
GTTGCTGAGA17410.001424.6-kD protein (M93980)
GACGGCTAAA2150.0015No match
TCCCCCGTAC2150.0015No match
TTTTGAGTGA1210.0016No match
GCGCCAGCTC118780.0016Ubiqutin C-terminal hydrolase L1
AAACGAAAGT2260.0017ESTs, highly similar to S-ADENOSYLMETHIONINE SYNTHETASE γ form (R. norvegicus)
GCGGGCACCA2050.0017ESTs
ACAGGAAGGA1120.0018No match
ACTTCGTCCA090.0019No match
GAGTCACTCT090.0019ESTs
GCGGGTCGCC1630.0020No match
GGGACCTAGG2370.0023Neuron-specific gene family member 2
GTCTGGGGGG2140.0024Monoglyceride lipase
GCTATGAGAA2690.0024Amyloid β (A4) precursor-like protein 1
CCCAGATATT1950.0028Tubulin, β-4
GTGGCAGGCG1110.0029No match
GTGTGCCCCC1110.0029ESTs, highly similar to HYPOTHETICAL 67.8-kD PROTEIN in GND1-ERG9 INTERGENIC REGIONS (Saccharomyces cerevisiae)
GCTTTTGGGA1320.0034No match
TGTAGTGTAA800.0035Ribosomal protein S8
CCGCCTGTGG14340.0036Synapsin I
TCCCCGTGCA2130.0039No match
TCTGGTCCGG1110.0041Flotillin 2
GCAGAGTGCG32140.0044Multiple matches
CCGCCGTGGG080.0044Microtubule-associated protein 7
GTTGTGATTT080.0044Ewing sarcoma homolog
TGAGCACTCC080.0044Follistatin-like
CCTTACCGCT30560.0046ESTs
TCCGTGGTTG28530.0049ESTs, moderately similar to BIOTIN CARBOXYLASE (Anabaena pcc7120)
TTCTGGCCTG10270.0050ESTs, highly similar to EST00098 protein (Homo sapiens)
GAGAGAAGAG1010.0051Microtubule-associated protein τ
GGGCAGGGAG1010.0051ESTs
GTTTGCTGTG1640.0053Cathepsin B
GCGGGTTCGC1220.0062No match
TGGTGCACGT1220.0062ESTs, weakly similar to similar to kinensin-like protein (Caenorhabditis elegans)
ATGAATTTTG1100.0065ESTs, highly similar to CELL DIVISION CONTROL PROTEIN 4 (S. cerevisiae)
CCATTGATCA1100.0065ESTs, highly similar to bithoraxoid-like protein (R. norvegicus)
CGGATAACCA1100.0065Proliferation-associated protein 1
GCTTGTGACG1100.0065Transaldolase 1
TTACAGCAGA1100.0065ESTs, weakly similar to ORF YGL231c (S. cerevisiae)
TGCAGTCCCC2120.0065No match
CCCCAGCCAG25480.0065Ribosomal protein S3
ATTGCTTAGA700.0070RNA-binding motif protein 3
CAGTAACTTC700.0070Aquaporin 4
CCCCGCCGCG700.0070Zinc finger protein, multitype 1
CCCCTCCCCA700.0070No match
GGCCTTTGTG700.0070ESTs, weakly similar to coded for by C. elegans cDNA CEESW58F
GGATACGTTT1750.0075ESTs
GGCGGGGCCC1750.0075ESTs, weakly similar to 230K bullous pemphigoid antigen BPM1 (Mus musculus)
AATCACTGGC070.0082ESTs, moderately similar to protein DS 1, 24K (H. sapiens)
CGACCCCGGG070.0082No match
CTAACCTCCA070.0082No match
GTGTTGTCGG070.0082ESTs, weakly similar to S1-1 protein (R. norvegicus)
TAAGCAGGAC070.0082No match
CGCTGGTTCC35600.0087Replication factor C, 140 kd
AACTGCACAC1330.0096ESTs, highly similar to SUCCINATE DEHYDROGENASE (H. sapiens)
GGGTCCTGCT8220.0097ESTs
CGCGGCAGGC38200.0104Dynactin 1
CAGGACTCCG63400.0106Stearoyl-Coenzyme A desaturase 2
CTCTTCCCCC42230.0110Phosphatidylethanolamine-binding mRNA, complete cds
TCCCCGTACT4150.0111No match
ACCAAGATCT3130.0112Ribosomal protein S19
ATGGGTCATC3130.0112ESTs, highly similar to TRANSLOCATION PROTEIN SEC62 (S. cerevisiae)
TCTGCCCTCC3130.0112No match
GATTCCGTGA39640.0113ESTs, highly similar to 60S RIBOSOMAL PROTEIN L37 (H. sapiens; R. norvegicus)
GCCAAAAAAA190.0113ESTs, highly similar to 2-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT PRECURSOR (H. sapiens)
GGCTTTGGAG190.0113ESTs, moderately similar to HSPC005 (H. sapiens)
ACTCGGAGCC23430.0114Calmodulin
CAAACTGAAG2110.0114ESTs, highly similar to spliceosomal protein SAP 155 (H. sapiens)
CACTACACGG2110.0114FK506-binding protein 2 (13 kD)
GGGGCTCAGC31150.0115Glucose phosphate isomerase 1 complex
GTACTGACAT9230.0116No match
GCAGCATCTG1650.0118ESTs
CTGGCAGAAG1120.0125ESTs, highly similar to NIFU PROTEIN [Anabaena pcc7120]
TCTGGAGACA1120.015No match
AGAGCTGTGG1440.0132NADH dehydrogenase flavoprotein 1
GTGTGTGGTG1970.0134ESTs
TGAGAACTGC1970.0134Tetratricopeptide repeat domain
TCAGGCTGCC1531990.0135Ferritin heavy chain
GTGTGCCGCT1760.0144No match
AAGCTCAGTT5160.0146ESTs
CCACAGAGCT5160.0146Ena-vasodilator stimulated phosphoprotein
AAAGTTCGGA600.0147sid23p
ATGCAACTAC13270.0211ESTs, highly similar to CYTOCHROME C OXIDASE POLYPEPTIDE VIB (Bos taurus)
TGGGGTTTCC44270.0214Multiple matches
GGGAGCGGGC22100.0217ESTs, Highly similar to HYPOTHETICAL 109.5 kD PROTEIN IN PPA1-DAP2 INTERGENIC REGION (S. cerevisiae)
TAACAGTTGT1340.0219Calnexin
AGAGAGGCCA180.0226ESTs, weakly similar to PROFLIN I (M. musculus)
AGGCATTGTC180.0226ESTs
CATCAGCCTC180.0226Multiple matches
CCCAGGCTTG180.0226ESTs
GACTCTTTCT180.0226ESTs
GGCCTCTAAA180.0226ESTs
TGCTGGTGCG180.0226ESTs
GGCAGTCCCC5150.0228ESTS
TTGGCTCACA5150.0228ESTs
GAATTTTTAC1660.0253No match
GGGCAAGCCA1770.0268Estrogen related receptor, α
TGGCTTTTCT28150.0277Multiple matches
ATCCTAGGTC1130.0277No match
CAGACGGAAG1130.0277ESTs
GGGAAAACTT1130.0277No match
GTCGGCCGCC1130.0277 M. musculus DNase1 precursor mRNA, complete cds
GGGATGGCCA8190.0287ESTs
AATATGTGTG6160.0298Cytochrome c oxidase, subunit Vlc
AACGCTGCCA25420.0299Macrophage migration inhibitory factor
AACGGCTAAC500.0302No match
AACTATTAAA500.0302ESTs
AAGAGAACCC500.0302No match
AAGCACTGTG500.0302ESTs
AAGTTGCATT500.0302NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 1
ACCTTGCCCT500.0302ESTs, highly similar to TRANSLOCON-ASSOCIATED PROTEIN, β SUBUNIT PRECURSOR (H. sapiens)
ACTCCCCAGA500.0302No match
CAAATCCTGT500.0302No match
CCAACAACTG500.0302No match
CCCAGGCTGA500.0302ESTS
CCCTTGAGTC500.0302No match
CCTTTCAAAA500.0302General transcription factor II I
CCTTTCAAAC500.0302ESTs, highly similar to similar to nuclear domain 10 protein NDP52 (H. sapiens)
CTGCATTAAG500.0302ESTs, highly similar to enoyl-CoA hydratase (H. sapiens)
CTTGCAATCT500.0302ESTs, weakly similar to HORMONE SENSITIVE LIPASE (M. musculus)
CTTTGGGGGC500.0302ESTs
CTTTTCAGCA500.0302No match
GAAAGGTCAG500.0302ESTs
GAACAGGACC500.0302ESTs
GACAAAAAAA500.0302ESTs
GATAATGCAC500.0302NADH dehydrogenase (ubiquinone) Fe-S protein 4 (18 kD)
GCACACACCC500.0302EST
GCCTGTCTTC500.0302ESTs
GGAATTTTTA500.0302ESTs
GGGGCTATCG500.0302No match
GGGGGCGCGC500.0302No match
GTGTAGACCA500.0302ESTS
TAGTGTTTTC500.0302No match
TCAAACTGCC500.0302No match
TCATCTTTAA500.0302Calreticulin
TCCTCACGTG500.0302Pyruvate dehydrogenase 2
TCTTTAATCC500.0302ESTs
AAGCCACAGA600.0147ESTs, moderately similar to PUTATIVE SURFACE GLYCOPROTEIN C21ORF1 PRECURSOR (H. sapiens)
AGCAGCCCCT600.0147No match
CACTGGGTTG600.0147ESTs, highly similar to unknown (H. sapiens)
CGGACGGCTT600.0147No match
GGGATTCCAG600.0147No match
GGTTCTGCCC600.0147ESTs
TAGTGGCGTA600.0147α-internexin neuronal intermediate filament protein
TGAGCCTGGT600.0147Latent transforming growth factor β binding protein 3
TGGAGAACTA600.0147ESTS
TGGCCAAGCC600.0147Polyhomeotic (mPh2) mRNA
TGTTCTTCCC600.0147No match
TTTGTGACTG600.0147C-terminal–binding protein 1
GCCTTTATGA12270.0155Ribosomal protein S24
TCCGGGCGAG1230.0163Replication-dependent histone H2A.1 gene
GAACTTGCAA1870.0175ESTs, moderately similar to FARNESYL PYROPHOSPHATE SYNTHETASE (R. norvegicus)
CGTCTGTGAA1020.0175No match
GGCCCCAAAC1020.0175V-crk-associated tyrosine kinase substrate
AACGTTGGAA060.0183ESTs, weakly similar to cytosolic inorganic pyrophosphatase (H. sapiens)
AACTTGGCTG060.0183Guanylate kinase membrane-associated inverted 1
AAGCTGCCCT060.0183ORNITHINE AMINOTRANSFERASE PRECURSOR
AGCCCATCAA060.0183ESTs
AGGAGGGGTA060.0183RAB24, member RAS oncogene family
ATTCTGGCAG060.0183ESTs, highly similar to UBIQUITIN-CONJUGATING ENZYME E2-17 KD 3 (H. sapiens; R. norvegicus)
CCGAATTACC060.0183Cornichon homolog (Drosophila)
CCTGTAATCC060.0183ESTs
CGGCCTACGT060.0183Superoxide dismutase 2, mitochondrial
GGCAGACTGT060.0183EST
GGGATCCAGG060.0183ESTs, weakly similar to coded for by C. elegans cDNA yk157f8.5
GGTAAAGTTA060.0183ESTs, weakly similar to MITOCHONDRIAL ELONGATION FACTOR TS PRECURSOR (H. sapiens)
GTCCTTTTTC060.0183ESTs, highly similar to ring-box protein 1 (M. musculus)
GTGGGGCGGG060.0183ESTs
TAACAAAGGA060.0183ESTS
TACCCCGTAC060.0183No match
TCCCCGTATA060.0183No match
TCTGGCAAAG060.0183EST
GCACCGAACA28140.0190sid23p
GAAGATGAGC36200.0192RAB3A, member RAS oncogene family
CAAAAATAAA25120.0197ESTs
GAGATGCCTG10230.0205ESTs, highly similar to NADH-UBIQUINONE OXIDOREDUCTASE 42 kD SUBUNIT PRECURSOR (B. taurus)
ACGTCGTGCG810.0206No match
CCTTTCTGTC810.0206No match
CTTTGGGGAC810.0206ESTS, Highly similar to Down syndrome candidate region 1 (H. sapiens)
GCAGGCTTCG810.0206ESTs, weakly similar to HYPOTHETICAL 54.9 kD PROTEIN C02F5.7 IN CHROMOSOME III (C. elegans)
GCCTGCCCCG810.02060cdc37 homolog
GGGCCCCGGG810.0206Multiple matches
AAGAGAACAC2100.0208No match
GGAGAAGAGC2100.0208No match
TACGGCTAAA2100.0208No match
AGAAAAAAAA3120.0209Multiple matches
GAGTGCCTGT3120.0209ESTs
TGACAGCTTG500.0302ESTs
TGAGCCAACT500.0302ESTs
TGAGTTACAG500.0302Nucleosome assembly protein 1-like 2
TGTGAGGCTC500.0302No match
TTCAGCTCGA33190.0303Ribosomal protein S7
CCGCCAAGGG920.0320ESTs, moderately similar to hTOM34p (H. sapiens)
GCAGGTCCCC920.0320ESTs
GGGCCCAACT920.0320EST
GGGGAGACGC920.0320Fibroblast growth factor receptor 1
TGCAGTGCAC920.0320ESTs
CTGCGAGATT25130.0322ESTs, highly similary to NADH-UBIQUINONE DEHYDROGENASE 24-kD SUBUNIT PRECURSOR (R. norvegicus)
AGAACTTCAA710.0327No match
CAGGGCGAGA710.0327ESTs, highly similar to hypothetical protein (H sapiens)
CTGGGCTTGA710.0327No match
GCAAGAGAGA710.0327Glutamine synthetase
GCCCTGGCCC710.0327No match
GGATCCCCAA710.0327ESTs
TCCAACTCCT710.0327ESTs, weakly similar to weak similarity to Bascillus stearothemophilus. 30S ribosomal protein S21 (C. elegans)
TGAACCCATT710.0327Cytochrome oxidase, subunit VIa, polypeptide 1
TGGAGGAGCT710.0327ESTs, highly similar to formin-binding protein 11 (M. musculus)
GAGACCATCG3110.0333ESTs, highly similar to (define not available 6013323< M. musculus)
GCGAGGAAGA3110.0333No match
GGGGAAATCG80590.0341ESTs, Moderately similar to THYMOSIN β-10 (H. sapiens; R. norvegicus; Equus caballus)
CCAGGCCGGG1560.0347Protein kinase C, ζ
GAGCCCCTTG1560.0347No match
TGGAATGCAG1560.0347Calnexin
AGTTGGAAAC1240.0356Nuclear factor of activated T-cells, cytoplasmic 2
CCCGTAGCCC1240.0356Tropomyosin 2, β
GCGCCCTGAT1240.0356No match
GGCACCATCT1240.0356No match
TACCCCAGGG1240.0356No match
TTGATCCCCA1240.0356Lysosomal membrane glycoprotein 1
GGGGCAGCCC36220.0357CornichonDrosophila-like
GCACAACTTG2131810.0361Multiple matches
CTACTGACAT290.0364No match
GCGAGGGAGC290.0364Dim1 (S. pombe)
GGAGCGCTAT290.0364ESTs
AAACATTGGG050.0366ESTs, weakly similar to Similar to S. cerevisiae EMP70 protein precursor (H. sapiens)
ACAACAAAAT050.0366ESTs
ACCCGCACCC050.0366No match
ACTCTTTCCT050.0366ESTs
ACTGTGTCTT050.0366ESTs
AGAGGCACTT050.0366ESTs, highly similar to ACETYL-COENZYME A SYNTHETASE (Escherichia coli)
AGATGGCTTT050.0366Mast cell-growth factor
AGCCGTGTAT050.0366ESTs
AGGCTGGTGA050.0366Proteasome (prosome, macropain) subunit, β type 1
CAAATGGACT050.0366ESTs
CACAGCGTTG050.0366No match
CACTTTTTTT050.0366No match
CCAAGGCTGC050.0366ESTs
CGGGACCCCA050.0366No match
CTAGTCGCAA050.0366ESTs, highly similar to THYMIDINE PHOSPHORYLASE (H. sapiens)
CTGTGTAATT050.0366ESTs
GAAACCAGGA050.0366ESTS, weakly similar to PLATELET-ENDOTHELIAL TETRASPAN ANTIGEN 3 (M. musculus)
GAATTGATGA050.0366Secretogranin II
GATCTGACCC050.0366ESTs
GCCACGCCCT050.0366No match
GCTTAAAAAT050.0366ESTS
GGAAGTTGGC050.0366No match
GGGAAGAGAT050.0366ESTs
GGTACCCCCA050.0366ESTs
GTTTTCTAGT050.0366ESTs, highly similar to PRE-mRNA SPLICING HELICASE BRR2 (S. cerevisiae)
TAGACCAGGC050.0366ESTs, weakly similar to VITAMIN K-DEPENDENT γ-CARBOXYLASE (H. sapiens)
TATGTCAAGT050.0366No match
TCCAGAAAAT050.0366No match
TCCCCGTTCA050.0366No match
TGAACTGTGT050.0366ESTs
TGGATGCTGG050.0366Adenomatosis polyposis coli binding protein Eb1
TGGGCCACAC050.0366ESTs, weakly similar to KIAA0990 protein (H. sapiens)
TTCCCCACGT050.0366Cell division cycle 2 homolog S. pombe-like 2
CAATAAACTG23120.0367Suppressor of initiator codon mutations-yeast homolog-related sequence 1
GGCTGGGGGC26140.0369Profilin 1
ACCGGTATTT5140.0376Protein kinase C, β
CCAATGCAGC5140.0376ESTs, highly similar to PROBABLE 3-OXOADIPATE COA-TRANSFERASE SUBUNIT B (Bacillus subtilis)
AAAGTGTTTC170.0379ESTs
ATCTCAAACC170.0379ESTs
CCTACAGTCC170.0379No match
CGCAATTCAA170.0379No match
GAGAAAGTTC170.0379ESTs
GGATGATGGT170.0379ESTs, highly similar to EXTRACELLULAR RIBONUCLEASE LE PRECURSOR (Lycopersicon esculentum)
GTCAGGGGGA170.0379ESTs
TCCCCGTCCA170.0379No match
TCCCTACTAA170.0379No match
TGAGCAGTGG170.0379No match
TGTGTTCCCA170.0379ESTs, weakly similar to (define not available 5931573, M. musculus
GGATTTGGCT45660.0388Keratin complex 2, basic, gene1
ATGAAACTTT1990.0393ESTs
TCAGAGGCCT22370.0396ESTs
AACAAAGCAA1030.0402ESTs, moderately similar to unknown (H. sapiens)
AGGCCAGCTG1030.0402Sema domain, immunoglobulin domain (lg), short basic domain, secreted, (semaphorin) 3F
GCCAAATTTG1030.0402ESTs, highly similar to 26S proteasome subunit p112 (R. norvegicus)
GGGCTGGAAT1030.0402ESTs
CTTGCAAGTG13250.0417ESTs, highly similar to NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT (B. taurus)
GAGTTCTCTG13250.0417ESTs, moderately similar to HSPC035 protein (H. sapiens)
GCTGGCAGCC32190.0417RAD9 homolog (S. pombe)
TTGGCTGCCC43280.0422Ribosomal protein S14
GTCTGCTGAT6150.0439Guanine nucleotide-binding protein, β-2, related sequence 1
GAGGAGTGGG9190.0461NO match
CTTCTCATTT3100.0462Membrane transporter protein
GGCAATTCAA3100.0462No match
TGTCGCCAGG3100.0462No match
CCAGAACAGA14260.0464Ribosomal protein L30
GCCTGTGGTG21110.0469Lymphocyte antigen 6 complex, locus H
GGGTGCAGCC25140.0470FK506-binding protein 8 (38 kD)
GTGCCCTCCA34210.047No match
TGGAACCTTG1350.0478ESTs
TTCTCCTCAG1350.0478ESTs, moderately similar to (define not available 5815343, M. musculus)
TATGCAACCC33210.0486Necdin
AAAACAGTGG15270.0489Ribosomal protein L37a
GGGAGGGAGG1780.0499No match
AGCAGTCCCT1140.0542Homogentisate 1,2-dioxygenase
CTCAGAAAGC1140.0502ATPase, H+ transporting, lysosomal (vacuolar proton pump), α 70 kD, isoform 2
GCTGCCTTCC1140.0502Harvey rat sarcoma virus oncogene
TGAACCTGAG1140.0502ESTs
CTCCTGCAGC5130.0508sid478p
GACGAGATTC5130.058ESTs, weakly similar to Lpe5p (S. cerevisiae)

[i] For each tag (tag sequence) the number of its copies in Ts65Dn library (Ts65Dn) and normal library (Normal) together with the estimated p-chance and GenBank matach (GenBank match) are shown. Complete table available as online supplementary material atwww.genome.org. An ongoing update of the table is available atmedger.unige.ch/research/projects.html.