Table 2.

Characterization of Seven Gene Transcripts Selected as Preferentially Expressed in Brain

GENX[i] Sequence similarity[ii] [iii]GenBank, SWISS-PROT* accession no. Genexpress clone (1NIB) name IMAGE clone ID GenBank/ EMBL accession no. Insert size (kb) Transcript size (kb) Chromosomal localization Orphan neurologic pathologies[iv]
465RELRattus norvegicus calcium- independent α-latrotoxin receptor U72487U78105 O09026 *O35818 * c-0obo334591 Z42577 F02089 1.47.54q12
769ID clone 23682 mRNA sequence ID clone 24440 mRNA sequence ID mRNA for KIAA0513 protein

U79288AF055005 AB011085
c-08e0857147 Z42089 F01625 1.77.516q24.3
3809ID protein Armadillo multigene family (Hatzfeld and Natchtsheim 1996)

X81889Q99569 *
c-01d1031734 Z42486 Z38681 1.54.62q22.3–q24.2
3960ID visinin-like protein1 (Polymeropoulos et al. 1995) U14747P42323 * c-11h0549279 F06242 F02525 1.522
4044REL mouse and cattle cyclin-dependent kinase regulatory subunit P35

S73375S82819
c-0ge0726501 Z42350 Z38574 1.84.217p11.2–q12DFNB3 DDPAC
4858ID human DNA sequence Chr22 Z99716 Z82192 c-03a1032335 Z41917 Z38211 1.86.0/2.622q13.1–q13.3
200991ID clone 23876 neuronal olfactomedin-related ER localized protein mRNA U79299AF035301 Q99784 * c-0oa0334458 F05835 F02082 1.42.69q34.1–34.3ALS4

[i] GENX number refers to the Genexpress Index 2 cluster of cDNA clones, sequences, and ESTS markers.

[ii] Classification of each GENX cluster is based on data base similarities. Sequences were classified as known (ID) if identical to a human sequence and related (REL) if having a partial similarity to a sequence in another species.

[iii] When a significant sequence similarity was found, the GenBank or SWISS-PROT (with an asterisk) accession no. is reported.

[iv] (DFNB3) Neurosensory recessive deafness 3; (DDPAC) frontotemporal dementia with parkinsonism with variable phenotypes; ALS4) familial ALS.