Table 2.

Putative Cases of Gene Overlap in the 3‘UTR (Truncated)

Accession no. hoG/direction Annotation and functional notes Chr. Map information Overlap (% identity)
X66397 TPR (tpr) mRNA, involved in activation of oncogenic kinases1GDB:1006915
U69668 human nuclear pore complex-associated protein TPR (tpr) mRNA1GDB:1006915
R.C.U70136 megakaryocyte growth and development factor33q26.3–q27142 bases (100%)
M63960 human protein phosphatase-I (PPPI) catalytic subunit mRNA, complete coding sequence
J04759 human PPPI α subunit (PPPIA) mRNA, 3‘ end11
X70848 human mRNA for PPPI catalytic subunit
S57501 PPPI catalytic subunit
R.C.U53174 human cell cycle checkpoint control protein mRNA, complete coding sequence231 bases (99%)
U40282 integrin-linked kinase (ILK)1111p15.5
R.C. U25816 TATA-binding protein-associated factor 301111p15.5
R.C.U13991 TATA-binding protein-associated factor II 301111p15.525 bases (100%)
L39891 Homo sapiens polycystic kidney disease-associated protein (PKD1) gene1616p13.33
U24497 human autosomal dominant PKD1 1616p13.3
L33243 H. sapiens PKD1 mRNA1616p13.3
R.C.L48546 H. sapiens tuberin (TSC2) gene1616p13.3 STS:  G27421 61 bases (100%)
L41816 CaMK I
R.C. AB000410 hOGG1, involved in the repair of oxidative DNA damage58 bases (100%)
S70154 human t-complex polypeptide 1 gene66pter
R.C. X52882 cytosolic acetoacetyl–coenzyme A thiolase6 G30038,  G11124;  6q25.392 bases (98%)

[i] Using the annotation, the 3‘ UTRs of full-length genes were extracted from UniGene 101 and subjected to cluster analysis. Twenty-one cases of possible gene overlap in the 3‘ UTR were isolated by looking for reverse complement matches in clusters. The R.C. notation prefixing the accession number signifies that the relative orientation is opposite that of genes without R.C. Where multiple accession nos. match the same gene, all are listed. Annotation, chromosomal assignment and mapping information, and number of bases overlap with sequence identity of match are given when available. For brevity, only a small portion of the result is shown here. The full table may be viewed as supplementary information athttp://www.genome.org.