Table 2.

Transcripts Identified by Sequencing the USH1C Critical Region

Contig (kb[i]) PAC Known genes STSs[ii] ESTc (%ID/length) (rep. clone)[iii] GRAIL exons[iv] CpG islands[v]
761  (7)169p3
765  (9)169p3 RP-S4/S25  pseudogenes[vi] SHGC315652
766 (13)239b22 SUR1 [vii] 5
767 (13)169p32
770 (25)169p3 D11S1228
771 (18)169p3/306b4 NEFA [viii] 6 (80/185)(R63988)1
773 (23)169p3/306b4 NEFA [viii] AFMb340wf55 (99/618)(R02788)31
774 (38)169p3/306b4 NEFA [viii] 4 (96/63)(AA091720)101
775 (50)239b2 SUR1 [vii] 1 (97/480)(H09680)182
776 (85)306b4/239b22 SUR1 [vii], BIR [ix] 2 (98/460)(H73741)294
3 (99/534)(W93954)
 Total sequenced 281

[i] Number of kilobase pairs in sequence contig. Genomic sequence data are available using GenBANK accession nos. AC000406 andAC000407.

[ii] Sequenced-tagged sites.

[iii] Expressed sequenced-tagged site cluster. (%ID/length) percent identity/length of homologous region, GenBank accession no. for representative clone.

[iv] Number of GRAIL-predicted exons of “excellent” quality.

[v] CpG islands as defined by Gardiner-Garden and Frommer (1987).

[vi] Pseudogenes for ribosomal proteins S4 and S25.

[vii] (SUR1) Sulfonylurea receptor 1 (GenBank accession nos. L78207L78243).

[viii] (NEFA) DNA binding/ EF-hand/acidic-amino acid rich protein (GenBank accession no. X76732).

[ix] (BIR) β-Cell inward rectifier potassium channel gene (GenBank accession no. D50582).