[i] The one-tail t-test indicates that observed gene numbers are significantly more than predicted values (P = 0.0004).

[ii] ^aT1–T11 are dog tumors (see Table 1 for more detailed description), whereas T2551 is a human MSI-none adenocarcinoma, and T3912 is a human MSI-high adenocarcinoma.

[iii] ^bThe predicted gene numbers were calculated by assuming that overlap between disrupted genes of each tumor and the human CRC pathway gene members (647 total) is completely random.