[i] ^aAll S. pneumoniae loci number (spr#) are according to the annotation of R6.

[ii] ^bThe genome of this mutant was not sequenced. Only the genes found mutated in 1974M2 were PCR amplified and sequenced in 1974M1.

[iii] ^cWhen the mutations are within coding regions, the change in amino acids is also indicated in italics.

[iv] ^dIn noncoding sequence. The number preceded by “-“ indicates the position upstream of the ATG.