^aIn vertebrate, IL-1 receptors share the same set of TIR adapters with Toll-like receptors.

^bPossible novel recognition receptors.

^cSimilar to plant TIR domain.

^dSimilar to bacterial TIR domain.

^eDFD can be present or absent.

^fEstimated to be less than 300–600 genes based on the analysis of trace archives.

^gThe first number refers to the gene number or model number; the second number refers to the domain number. 104 refers to those small CTL with carbohydrate-binding motifs (Hibino et al. 2006); 346 refers to the total domain number in the genome.

^hRefers to vertebrate DEATH domain adapters TRADD, FADD, CRADD, DEDD, LRDD, MADD.

NES, no evidence (EST, cDNA, homologs in other species, etc.) support.