Table 2.

Gene Ontology Functional Classification

GO functional classification Number of human orthologs Number in intermediate paralog set Number in close paralog set
Total for which classification was possible25254994 
Anticoagulant200 
Antioxidant100 
Apoptosis regulator2011 
Cell adhesion molecule13325 
Cell cycle regulator3813 
Chaperone16015 
Chaperone regulator1702 
Defense/immunity protein7614 
Enzyme13952956 
Enzyme regulator10716 
Ligand binding or carrier11212538 
Lysine1000 
Molecular function unknown11314 
Motor3311 
Nucleic acid binding5951732 (0.02[i])
Obsolete8804 
Protein stabilization100 
Protein tagging101 
Signal transducer9921439 
Storage protein200 
Structural protein16836 
Toxin900 
Transporter486815 

[i] P values have been calculated from a two-tailed Fisher's exact test and are shown for values <0.05. Correction for multiple tests has not been performed.