Summary of Suggestive and Significant Linkages
| Marker[i] | Position | Population[iv] | Mode of inheritance[v] | LOD[vi] | % of Phenotypical variance explained[vii] | Allele increasing phenotypical score | |||||||
| MIT[ii] | MGD[iii] | ||||||||||||
| 3% Ethanol intake | |||||||||||||
| D4Mit42 | 76.5 | 81.0 | Males | B6-dominant | 2.65[ix] | 14.7 | B6 | ||||||
| D8Mit95 | 6.6 | 8.0 | Males | Additive | 1.92[ix] | 11.1 | B6 | ||||||
| D9Mit25 | 20.8 | 26.0 | Males | 129-dominant | 2.61[ix] | 17.6 | B6 | ||||||
| D12Mit46 | 13.1 | 17.0 | Both genders | B6-dominant | 2.75[ix] | 8.5 | 129 | ||||||
| D17Mit6 | 27.3 | 31.0 | Both genders | 129-dominant | 3.13[ix] | 8.3 | 129 | ||||||
| D18Mit55 | 16.4 | 25.0 | Both genders | Additive | 2.24[ix] | 7.0 | B6 | ||||||
| 3% Ethanol preference | |||||||||||||
| D2Mit12 | 50.3 | 50.3 | Both genders | 129-dominant | 2.22[ix] | 6.0 | 129 | ||||||
| D8Mit95 | 6.6 | 8.0 | Males | Additive | 3.65[x] | 19.3 | B6 | ||||||
| D17Mit6 | 27.3 | 31.0 | Both genders | 129-dominant | 2.09[ix] | 5.6 | 129 | ||||||
| 10% Ethanol intake | |||||||||||||
| D4Mit256 | 82.0 | 82.7 | Both genders | B6-dominant | 4.47[x] | 13.3 | B6 | ||||||
| D7Mit69 | 20.8 | 24.5 | Both genders | B6-dominant | 4.37[x] | 11.8 | 129 | ||||||
| 10% Ethanol preference | |||||||||||||
| D2Mit168 [viii] | 66.7 | 81.7 | Both genders | Additive | 1.94[ix] | 5.4 | 129 | ||||||
| D4Mit256 | 82.0 | 82.7 | Both genders | B6-dominant | 2.92[ix] | 8.7 | B6 | ||||||
| D13Mit147 | 37.2 | 51.0 | Both genders | Additive | 1.93[ix] | 5.3 | B6 | ||||||
[i] Marker showing the strongest linkage.
[ii] MIT—MIT/Whitehead Institute database (http://www-genome.wi.mit.edu/).
[iii] MGD—Mouse Genome Database at The Jackson Laboratory (http://www.informatics.jax.org/).
[iv] Only one gender is shown when linkage was above significant or suggestive threshold for this gender, but not for the other gender or for the combined sample of both genders. Note that linkage for distal chromosome 4 is present in both genders for 10% ethanol intake and preference (D4Mit256) and is male-specific for 3% ethanol intake (D4Mit42).
[v] Estimated based on LOD scores calculated usingMAPMAKER/QTL under unconstrained, additive, recessive, and dominant models.
[vi] LOD, logarithm of the odds ratio. Estimated for the most likely mode of inheritance.
[vii] Estimated for the unconstrained model.
[viii] For 10% ethanol preference, peak LOD score on chromosome 2 was at the agouti coat color locus (LOD 2.2, explained 6.6% of phenotypical variance, unconstrained model), but because this is a dominant marker (genotypes AA and Aa cannot be distinguished), mode of inheritance for this QTL was assessed based on genotype of another linked marker, D2Mit168.
[ix] Suggestive linkage (LOD thresholds 1.9 for additive and 2.0 for dominant/recessive models).
[x] Significant linkage (logarithm of the odds ratio (LOD) thresholds 3.3 for additive and 3.4 for dominant/recessive models).