Reaction Subsets for Lysine Synthesis in H. influenzae
| 1 | THRA1, ASD, DAPA, DAPB, DAPD, DAPC, DAPF, LYSA, GDHA, ASPC2, FBA, TPIA, GAPA, PGK, GPMA, ENO, SUCCD, PPC, FRUTR, FRUK, PTA, ACKA, CO2TR, ACTR, NH3TR, ACxt, CO2xt, FRUxt, NH3xt, LYS |
| 2 | SERA, SERC, SERB |
| 3 | GLYA, GCV, FMT, FOLD1, FOLD2 |
| 4 | ASNA, ANSB, ADK1 |
| 5 | ASPA, FUMC |
| 6 | PGI1, ZWF, GND, RPIA, RPE, TALB, TKTA1, TKTA2, PGL |
| 7 | ACCABCD, FABD, FABH, FABB |
| 8 | DGKA, PAPHTSE |
| 9 | GLMS, NAGB |
| 10 | PYRG, NDK2, NDK3, CDD1, CMKB2, CMKB3, USHA6 |
| 11 | NDK1, UDK |
| 12 | NDK5, TMK2, DUT |
| 13 | TDK1, USHA2 |
| 14 | TDK2, USHA1 |
| 15 | GLGC, GLGA, GLGP |
| 16 | GLPA, GPSA |
| 17 | CYDA, O2TR, O2xt |
| 18 | MGSA, GLOA, GLOB |
[i] Each of the reactions subsets above are correlated in the extreme pathways that correspond to lysine synthesis in H. influenzae. For example, in every extreme pathway, the reactions TDK2 and USHA1 (group 14) are either used or not used together. Group I contains the reactions that are always utilized (region I in Fig. 4) and Groups 2–18 above are in the variable region (region II in Fig.4)