Effects of the Mom1 and Mom2 Loci on Polyp Multiplicity in the Small Intestine of N2 Offspring from the B6 × D2B6F1 ApcMin and D2 × D2B6F1ApcMin Backcrosses[i]
| Genotypes of B6 × D2B6F1 Apc Min N2 offspring | Mom1 S /Mom1 S | Mom1 R /Mom1 S | pvalues |
| Mom2+/Mom2+ | 130.6 ± 51.6 (7) | 60.6 ± 16.9 (8) | p< 0.005 |
| Mom2R/Mom2+ | 7.8 ± 5.1 (35) | 3.2 ± 2.9 (29) | p< 0.001 |
| p values | p < 0.001 | p < 0.001 |
| Genotypes of D2 × D2B6F1 Apc Min N2 offspring | Mom1 R /Mom1 S | Mom1 R /Mom1 R | Total |
| Mom2+/Mom2+ | 58.3 ± 17.9 (3) | 78.0 ± 2.8 (2) | 65.4 ± 16.1 (5) |
| Mom2R/Mom2+ | 7.8 ± 4.5 (9) | 8.3 ± 7.9 (7) | 8.0 ± 6.0 (16) |
| pvalues | p < 0.001 |
[i] N2 progeny of D2B6F1 ApcMin /+ parents #5, #6, and #7 from Table 1 were classified according to strain background as well as genotype and phenotype at the Mom1 andMom2 loci, respectively. Average polyp numbers are shown ± standard deviation. The number of offspring in each group is shown in parentheses. P values were determined by the two sample t-test.