Markup | Genome Research

Table 2.

A List of ESTs That Were Found to be Differentially Expressed Based on Their Range of Numeric Expression Value and At Least a Threefold Difference in Expression Between NOV-31 and Any EOC Cell Line

Accession no.	Gene symbol	Description	Function[ii]	Expression values and reliability scores[i]
Accession no.	Gene symbol	Description	Function[ii]	NOV-31	TOV-81D	TOV-112D	OV-90	TOV-21G
D42043	KIAA0084	Hypothetical protein kiaa0084	Unknown.	181 P	178 P	11 A	28 P	55 P
X77777	VIPR1	vasoactive intestinal peptide receptor 1	This is a receptor for vasoactive intestinal polypeptide. The activity of this receptor is mediated by G-proteins which activate adenylyl cyclase.	192 P	−27 A	−41 A	−93 A	−18 A
M83751	ARP	arginine rich protein	Unknown.	112 P	213 P	166 P	876 P	108 A
R15944	GC20	translation factor sui1 homolog	Translation factor.	90 P	40 P	288 P	114 P	112 P
R42501	IMPDH2	Inosine monophosphate dehydrogenase-2	IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.	7 A	50 P	217 P	14 A	43 A
R55310	UQCRC1	ubiquinol-cytochrome c reductase core protein I	This is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.	23 A	43 M	160 P	50 M	−257 A
R46069	EST		Unknown.	44 P	15 A	162 P	80 P	−3 A
H05285	QARS	glutamine-tRNA synthetase	Part of a multisubunit complex that groups tRNA ligases for arg, asp, glu, gln, ile, leu, lys, met and pro.	32 P	15 A	168 P	32 P	79 P
T70046	FLNB	filamin B, beta (actin-binding protein-278)	Dimeric actin cross-linking phosphoprotein of the peripheral cytoplasm, interacts with the cytoplasmic tail of glycoprotein GP1BA.	320 P	190 P	61 P	944 P	170 P
R88575	TKT	transketolase (WernickeKorsakoff syndrome)	Key enzyme in the pentose-phosphate pathway.	36 P	59 P	137 P	113 P	417 P
X12892	PROS1	protein S (alpha)	Protein S, alpha coagulation factor (cofactor of proC), vitamin K-dependent, ligand for TYRO3, AXL family of receptor tyrosine kinase.	8 A	32 P	77 P	73 P	241 P
H56192	NR1D2	nuclear receptor subfamily 1, group D, member 2	Binds to the sequences 5′-aatgtaggtca-3′ and 5′-ataactaggtca-3′. Acts as a potent competitive repressor of ror α function (by similarity).	10 A	10 A	15 P	7 A	609 P
M37984	TNNC1	troponin C1, slow	Troponin is the central regulatory protein of striated muscle contraction.	10 A	17 A	50 P	98 P	205 P
X04828	GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	Guanine nucleotide-binding proteins (G-proteins) are involved as modulators or transducers in various transmembrane signaling systems.	198 P	122 P	101 P	84 A	16 A
H11650	ARF4	ADP-ribosylation factor 4	GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking.	391 P	548 P	225 P	228 P	19 A
T55741	MYLK	myosin, light polypeptide kinase	Phosphorylates specific serine in N terminus of a myosin light chain.	290 P	35 P	13 A	−4 A	−3 A
Y00281	RPN1	ribophorin 1	Essential subunit of N-oligosaccharyl transferase.	147 P	167 P	203 P	556 P	178 P
H22939	GYG	glycogenin	Protein primer required for the biogenesis of muscle glycogen. Elongation of the primer is effected by glycogen synthase.	191 M	113 P	210 M	57 A	120 P
H41528	DLG1	discs, large (Drosophila) homolog 1	Interacts with the cytoplasmic tail of nmda receptor subunits. Associates with protein 4.1	154 P	61 P	49 P	29 A	56 P
R23889 X01060	TFRC	transferrin receptor	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor.	254 P 80 P	392 P 237 P	114 P 45 P	780 P 288 P	283 P 151 P
R22228	HRY	hairy (Drosophila)homolog	Drosophila hairy pair rule gene homolog, also homolog to rat RHL, an immediated early response gene to growth factor.	−5 A	1 A	22 P	332 P	27 P
U25441	DRD3	dopamine receptor D3	This is one of five types (d1 to d5) of receptors for dopamine. The activity of this receptor is mediated by G-proteins which inhibit adenylyl cyclase.	−13 A	10 A	−31 A	−4 A	175 A
H20503	NDUFB7	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 (18 kD, B18)	Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	28 P	12 A	48 P	62 P	294 P
H88250	SFRS10	splicing factor, arginine/serine-rich (transformer 2 Drosophila homolog) 10	Splicing factor.	41 P	45 P	148 P	116 P	156 P

[i] Numeric expression values before standardization and the reliability score for each expression value were generated by the Affymetrix GeneChip software based on hybridization signals for probe sets representing each EST.

[ii] The function was retrieved from the Weizman Gene Card database (www.bioinfo.weizman.ca).