Table 2.

Expression of Genes Implicated Previously in Lifespan and Dauer

Gene Dauer tags Mixed tags Significance[i]
C15F1.b (sod-1) superoxide dismutase (Giglio et al. 1994)60590.96
F55H2.1 (sod-4) superoxide dismutase (Fujii et al. 1998)2650
C08A9.1 (sod-3) Manganese superoxide dismutase (Honda and Honda 1999)1800
ZK430.1 superoxide dismutase00NA
T24H7.1 prohibitin-like (Coates et al. 1997)310.39
ZC395.2 (clk-1) (Lakowski and Hekimi 1996)8100.60
C12D8.10a/b (akt-1) protein kinase (Paradis and Ruvkun 1998)2860
B0334.8 (daf-23,age-1) phosphatidylinositol-3-OH kinase (Larsen et al. 1995)630.33
C11E4.1 glutathione peroxidase (Vanfleteren 1993)68150
C11E4.2 glutathione peroxidase (Vanfleteren 1993)1720
R03G5.5 glutathione peroxidase (Vanfleteren 1993)200.09
F26E4.12 glutathione peroxidase (Vanfleteren 1993)210.57
Y54G11A.6 catalase (ctl-1) (Vanfleteren 1993; Taub et al. 1999)1570.10
Y54G11A.5a/b peroxisomal catalase (Vanfleteren 1993)1170.37
ZC395.6 (gro-1) (Hodgkin and Doniach 1997)040.02
R11A8.4 (sir-2) Yeast regulatory protein SIR2-like (Tissenbaum and Guarente 2001)230.63
H42K12.1 (pdk-1) Akt/PKB kinase like (Paradis et al. 1999)00NA
Y55D5A.b (daf-2) Insulin receptor-like (Kimura et al. 1997)110.98
T28B8.2 (ins-1) Insulin-like (Pierce et al. 2001)610.05
R13H8.1 (daf-16) HNF-3/forkhead family member (Lin et al. 1997)NA[ii]
R10H10.2 (spe-26) (Varkey et al. 1995)00NA
C08H9.5 (cold-1) Protein tyrosine kinase (Rikke et al. 2000)410.17
F29C4.1 (daf-1) Protein kinase (Georgi et al. 1990)330.97
F25E2.5 (daf-3) Smad protein (Patterson et al. 1997)350.45
C05D2.1a (daf-4) Receptor protein kinase (Estevez et al. 1993)130.29
B0412.2 (daf-7) TGF-β (Ren et al. 1996)240.39
B0240.3 (daf-11) transmembrane guanylyl cyclase (Birnby et al. 2000)060
T07A9.6 (daf-18) PTEN homolog (Ogg and Ruvkun 1998)180.01
F33H1.1 (daf-19) RFX-type transcription factor (Swoboda et al. 2000)NA[ii]

[i] Significance indicates the probability of the null hypothesis that no difference exists between the expression in both dauer and mixed stage populations, determined by the G test (Sokal and Rohlf 1995).

[ii] Indicates genes for which SAGE tags could not unambiguously identify the transcript profile.