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Table 2.

Top 25 Genes More Highly Expressed in ALL Than in AML

Gene description	Probe	Difference	S.E.	Z-score	P-value[ii]	Fold diff[iii]	t-test[iv]	t rank[v]	ut-test[vi]	ut rank[vii]	W. r.s.[viii]	W rank⁸
C-myb	U22376	−3183.79	429.30	−7.42	<0.0001	5.39	0.1827	7	<0.0001	1	0.0371	2
p48	X74262	−1115.97	152.35	−7.33	<0.0001	5.24	0.2268	8	<0.0001	2	0.0911	6
Proteasome iota chain	X59417	−3331.23	481.79	−6.91	<0.0001	3.94	0.3777	12	<0.0001	3	0.3756	23
Myosin light chain (alkali)	M31211	−408.99	59.50	−6.87	<0.0001	3.57	0.1584	5	<0.0001	4	0.2854	19
Macmarcks	HG1612–	−2512.37	372.76	−6.74	<0.0001	2.87	0.2555	9	<0.0001	5	0.0432	3
	HT1612
Transcription factor 3 (E2A)	M65214	−471.84	70.04	−6.74	<0.0001	1.56	0.1759	6	<0.0001	6	0.8348	>59
Inducible protein	L47738	−1055.39	159.50	−6.62	<0.0001	6.64	0.7782	23	0.0012	7	0.0584	5
MB-1 (CD79b)	U05259	−3399.02	523.02	−6.50	<0.0001	12.26	1.0000	>28	0.0016	8	1.0000	>59
Crystallin zeta (quinone reductase)	L13278	−118.93	18.33	−6.49	<0.0001	27.36	0.4366	16	0.0018	9	0.5629	37
Transcriptional activator hSNF2b	D26156	−766.23	118.24	−6.48	<0.0001	2.35	0.3940	13	0.0019	10	0.4304	18
Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	M91432	−669.68	104.25	−6.42	<0.0001	4.29	1.0000	>28	0.0020	11	0.1626	11
Oncoprotein 18	M31303	−2013.15	314.83	−6.39	<0.0001	2.12	0.0309	2	0.0029	13	0.1874	13
Thymopoietin beta	U09087	−125.08	19.56	−6.39	<0.0001	3.43	0.8446	26	0.0023	12	0.3277	22
Cyclin D3	M92287	−3025.10	484.75	−6.24	<0.0001	3.86	1.0000	>28	0.0035	14	0.0911	7
Serine kinase SRPK2	U88666	−105.40	16.98	−6.21	<0.0001	2.08	0.4101	15	0.0044	17	0.7333	44
Transcription factor 3 (E2A)	M31523	−1044.46	169.32	−6.17	<0.0001	4.38	1.0000	>28	0.0043	15	0.0371	1
Adenosine triphosphatase, calcium	Z69881	−1809.52	293.38	−6.17	<0.0001	7.26	1.0000	>28	0.0043	16	0.6423	39
IEF SSP 9502	L07758	−278.58	45.28	−6.15	<0.0001	2.06	0.5292	19	0.0052	18	0.2483	18
Minichromosome maintenance deficient 3	D38073	−598.54	97.78	−6.12	<0.0001	2.85	0.8160	24	0.0055	20	0.4921	29
Cytoplasmic dynein light chain 1	U32944	−1349.78	221.68	−6.09	<0.0001	5.16	1.0000	>28	0.0054	19	1.0000	>59
Aldehyde reductase 1	X15414	−818.57	135.98	−6.02	<0.0001	2.26	0.0312	20	0.0090	24	0.4305	27
Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	J05243	−732.24	122.22	−5.99	<0.0001	6.26	1.0000	>28	0.0078	21	0.1626	12
Rabaptin-5	Y08612	−220.83	36.90	−5.98	<0.0001	2.20	1.0000	>28	0.0079	23	1.0000	>59
Topoisomerase (DNA) II beta	Z15115	−2927.58	490.37	−5.97	<0.0001	3.20	1.0000	>28	0.0079	22	0.0678	5
HKR-T1	S50223	−287.95	48.38	−5.95	<0.0001	5.68	0.5208	18	0.0097	25	1.0000	>59

[i] Dataset from Golub et al. (1999).

[ii] P-value computed from Z-score using a modified Bonferroni's correction.

[iii] P-value obtained from t-test with equivalent variances using a modified Bonferroni's correction.

[iv] Relative ranking by significance values obtained from t-test with equivalent variances. >28 indicates that the gene was not ranked because the P-value was 1.0.

[v] P-value obtained from t-test with unequal variances using a modified Bonferroni's correction.

[vi] Relative ranking by significance values obtained from t-test with unequal variances.

[vii] P-value obtained from Wilcoxon rank sum using a modified Bonferroni's correction.

[viii] Relative ranking by Wilcoxon significance values. >59 indicates that the gene was not ranked because the P-value was 1.0.